Abstract
Purpose: Smoking worsens quality of life among HIV-infected individuals, but it remains unclear if this association is related simply to smoking or to chronic obstructive pulmonary disease (COPD), the end-organ disease caused by smoking. Methods: Using cross-sectional data from the AIDS Linked to the Intravenous Experience study, we determined the independent effects of smoking, HIV and COPD assessed using the Medical Outcome Studies-HIV questionnaire. Results: Of 973 participants, 287 (29.5%) were HIV infected and 151 (15.5%) had spirometry-defined obstruction. Eight hundred and thirty-four (85.7%) were current smokers with 23.3 mean pack-years history. HIV infection was independently associated with reduced physical and mental health. COPD was associated with a trend toward worse physical health (-1.48 units; 95%CI -3.33 to 0.38; p = 0.12) and was independently associated with worse mental health (-2.43 units; 95%CI -4.22 to -0.64; p <0.01). After accounting for COPD and other covariates, smoking was not associated with changes in physical or mental health. Conclusions: The presence of COPD, rather than smoking, is associated with worse quality of life independent of HIV infection. Diagnosis and management of COPD in former or current smokers with or at risk for HIV may further improve quality of life.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1295-1302 |
| Number of pages | 8 |
| Journal | Quality of Life Research |
| Volume | 19 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 2010 |
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Keywords
- Chronic obstructive pulmonary disease
- Human immunodeficiency virus
- Injection drug use
- Quality of life
- Smoking
- Tobacco use
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Medicine(all)
Cite this
HIV and COPD : Impact of risk behaviors and diseases on quality of life. / Drummond, M. Bradley; Kirk, Gregory D; McCormack, Meredith; Marshall, Mariah M.; Ricketts, Erin P.; Mehta, Shruti Hemendra; Wise, Robert A; Merlo, Christian.
In: Quality of Life Research, Vol. 19, No. 9, 11.2010, p. 1295-1302.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV and COPD
T2 - Impact of risk behaviors and diseases on quality of life
AU - Drummond, M. Bradley
AU - Kirk, Gregory D
AU - McCormack, Meredith
AU - Marshall, Mariah M.
AU - Ricketts, Erin P.
AU - Mehta, Shruti Hemendra
AU - Wise, Robert A
AU - Merlo, Christian
PY - 2010/11
Y1 - 2010/11
N2 - Purpose: Smoking worsens quality of life among HIV-infected individuals, but it remains unclear if this association is related simply to smoking or to chronic obstructive pulmonary disease (COPD), the end-organ disease caused by smoking. Methods: Using cross-sectional data from the AIDS Linked to the Intravenous Experience study, we determined the independent effects of smoking, HIV and COPD assessed using the Medical Outcome Studies-HIV questionnaire. Results: Of 973 participants, 287 (29.5%) were HIV infected and 151 (15.5%) had spirometry-defined obstruction. Eight hundred and thirty-four (85.7%) were current smokers with 23.3 mean pack-years history. HIV infection was independently associated with reduced physical and mental health. COPD was associated with a trend toward worse physical health (-1.48 units; 95%CI -3.33 to 0.38; p = 0.12) and was independently associated with worse mental health (-2.43 units; 95%CI -4.22 to -0.64; p <0.01). After accounting for COPD and other covariates, smoking was not associated with changes in physical or mental health. Conclusions: The presence of COPD, rather than smoking, is associated with worse quality of life independent of HIV infection. Diagnosis and management of COPD in former or current smokers with or at risk for HIV may further improve quality of life.
AB - Purpose: Smoking worsens quality of life among HIV-infected individuals, but it remains unclear if this association is related simply to smoking or to chronic obstructive pulmonary disease (COPD), the end-organ disease caused by smoking. Methods: Using cross-sectional data from the AIDS Linked to the Intravenous Experience study, we determined the independent effects of smoking, HIV and COPD assessed using the Medical Outcome Studies-HIV questionnaire. Results: Of 973 participants, 287 (29.5%) were HIV infected and 151 (15.5%) had spirometry-defined obstruction. Eight hundred and thirty-four (85.7%) were current smokers with 23.3 mean pack-years history. HIV infection was independently associated with reduced physical and mental health. COPD was associated with a trend toward worse physical health (-1.48 units; 95%CI -3.33 to 0.38; p = 0.12) and was independently associated with worse mental health (-2.43 units; 95%CI -4.22 to -0.64; p <0.01). After accounting for COPD and other covariates, smoking was not associated with changes in physical or mental health. Conclusions: The presence of COPD, rather than smoking, is associated with worse quality of life independent of HIV infection. Diagnosis and management of COPD in former or current smokers with or at risk for HIV may further improve quality of life.
KW - Chronic obstructive pulmonary disease
KW - Human immunodeficiency virus
KW - Injection drug use
KW - Quality of life
KW - Smoking
KW - Tobacco use
UR - http://www.scopus.com/inward/record.url?scp=78349310305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78349310305&partnerID=8YFLogxK
U2 - 10.1007/s11136-010-9701-x
DO - 10.1007/s11136-010-9701-x
M3 - Article
VL - 19
SP - 1295
EP - 1302
JO - Quality of Life Research
JF - Quality of Life Research
SN - 0962-9343
IS - 9
ER -