HIV and ageing

improving quantity and quality of life

Keri Althoff, Mikaela Smit, Peter Reiss, Amy C. Justice

Research output: Contribution to journalArticle

Abstract

PURPOSE OF REVIEW: Evidence-based strategies are needed to address the growing complexity of care of those ageing with HIV so that as life expectancy is extended, quality of life is also enhanced. RECENT FINDINGS: Modifiable contributing factors to the quantity and quality of life in adults ageing with HIV include: burden of harmful health behaviours, injury from HIV infection, HIV treatment toxicity and general burden of age-associated comorbidities. In turn, these factors contribute to geriatric syndromes including multimorbidity and polypharmacy, physiologic frailty, falls and fragility fractures and cognitive dysfunction, which further compromise the quality of life long before they lead to mortality. SUMMARY: Viral suppression of HIV with combination antiviral therapy has led to increasing longevity but has not enabled a complete return to health among ageing HIV-infected individuals (HIV+). As adults age with HIV, the role of HIV itself and associated inflammation, effects of exposure to antiretroviral agents, the high prevalence of modifiable risk factors for age-associated conditions (e.g. smoking), and the effects of other viral coinfections are all influencing the health trajectory of persons ageing with HIV. We must move from the simplistic notion of HIV becoming a ‘chronic controllable illness’ to understanding the continually evolving ‘treated’ history of HIV infection with the burden of age-associated conditions and geriatric syndromes in the context of an altered and ageing immune system.

Original languageEnglish (US)
JournalCurrent Opinion in HIV and AIDS
DOIs
StateAccepted/In press - Jun 29 2016

Fingerprint

Quality of Life
HIV
Geriatrics
HIV Infections
Comorbidity
Anti-Retroviral Agents
Polypharmacy
Health Behavior
Health
Life Expectancy
Coinfection
Antiviral Agents
Immune System
Chronic Disease
Smoking
Inflammation
Mortality
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Oncology(nursing)
  • Immunology
  • Infectious Diseases
  • Virology
  • Oncology

Cite this

HIV and ageing : improving quantity and quality of life. / Althoff, Keri; Smit, Mikaela; Reiss, Peter; Justice, Amy C.

In: Current Opinion in HIV and AIDS, 29.06.2016.

Research output: Contribution to journalArticle

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