HIV-1/HIV-2 versus samhd1 restriction: A tale of two viruses

Wei Wei, Xiao Fang Yu

Research output: Contribution to journalShort surveypeer-review


The deoxynucleoside triphosphate triphosphohydrolase SAMHD1 is a myeloid cell-specific retroviral restriction factor that can be inactivated by viral protein Vpx from HIV-2 and certain SIV. In this issue of Cell Host & Microbe, Kyei et al. (2015) report that cyclin L2 enhances HIV-1 infection in macrophages by regulating SAMHD1.

Original languageEnglish (US)
Pages (from-to)8-9
Number of pages2
JournalCell Host and Microbe
Issue number1
StatePublished - Jan 14 2015

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology


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