HIV-1 viral load blips are of limited clinical significance

Patricia K. Lee, Tara L. Kieffer, Robert F Siliciano, Richard E. Nettles

Research output: Contribution to journalArticle

Abstract

Many patients on highly active antiretroviral therapy (HAART) who achieve undetectable HIV-1 RNA levels experience transient episodes of detectable viraemia or blips, suggesting there is incomplete suppression of viral replication. This raises concern that drug resistance mutations could develop and cause eventual treatment failure. However, data from recent studies indicate that most blips are actually random biological and statistical variations around a mean viral load below detectable levels (

Original languageEnglish (US)
Pages (from-to)803-805
Number of pages3
JournalThe Journal of antimicrobial chemotherapy
Volume57
Issue number5
DOIs
StatePublished - May 2006

Fingerprint

Viremia
Highly Active Antiretroviral Therapy
Viral Load
Treatment Failure
Drug Resistance
HIV-1
RNA
Mutation

Keywords

  • Drug resistance
  • Genotypes
  • HAART
  • HIV

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

Cite this

HIV-1 viral load blips are of limited clinical significance. / Lee, Patricia K.; Kieffer, Tara L.; Siliciano, Robert F; Nettles, Richard E.

In: The Journal of antimicrobial chemotherapy, Vol. 57, No. 5, 05.2006, p. 803-805.

Research output: Contribution to journalArticle

Lee, Patricia K. ; Kieffer, Tara L. ; Siliciano, Robert F ; Nettles, Richard E. / HIV-1 viral load blips are of limited clinical significance. In: The Journal of antimicrobial chemotherapy. 2006 ; Vol. 57, No. 5. pp. 803-805.
@article{4d822ba211a145ce91c95e75bd5bd01a,
title = "HIV-1 viral load blips are of limited clinical significance",
abstract = "Many patients on highly active antiretroviral therapy (HAART) who achieve undetectable HIV-1 RNA levels experience transient episodes of detectable viraemia or blips, suggesting there is incomplete suppression of viral replication. This raises concern that drug resistance mutations could develop and cause eventual treatment failure. However, data from recent studies indicate that most blips are actually random biological and statistical variations around a mean viral load below detectable levels (",
keywords = "Drug resistance, Genotypes, HAART, HIV",
author = "Lee, {Patricia K.} and Kieffer, {Tara L.} and Siliciano, {Robert F} and Nettles, {Richard E.}",
year = "2006",
month = "5",
doi = "10.1093/jac/dkl092",
language = "English (US)",
volume = "57",
pages = "803--805",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - HIV-1 viral load blips are of limited clinical significance

AU - Lee, Patricia K.

AU - Kieffer, Tara L.

AU - Siliciano, Robert F

AU - Nettles, Richard E.

PY - 2006/5

Y1 - 2006/5

N2 - Many patients on highly active antiretroviral therapy (HAART) who achieve undetectable HIV-1 RNA levels experience transient episodes of detectable viraemia or blips, suggesting there is incomplete suppression of viral replication. This raises concern that drug resistance mutations could develop and cause eventual treatment failure. However, data from recent studies indicate that most blips are actually random biological and statistical variations around a mean viral load below detectable levels (

AB - Many patients on highly active antiretroviral therapy (HAART) who achieve undetectable HIV-1 RNA levels experience transient episodes of detectable viraemia or blips, suggesting there is incomplete suppression of viral replication. This raises concern that drug resistance mutations could develop and cause eventual treatment failure. However, data from recent studies indicate that most blips are actually random biological and statistical variations around a mean viral load below detectable levels (

KW - Drug resistance

KW - Genotypes

KW - HAART

KW - HIV

UR - http://www.scopus.com/inward/record.url?scp=33645830940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645830940&partnerID=8YFLogxK

U2 - 10.1093/jac/dkl092

DO - 10.1093/jac/dkl092

M3 - Article

C2 - 16533823

AN - SCOPUS:33645830940

VL - 57

SP - 803

EP - 805

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 5

ER -