TY - JOUR
T1 - HIV-1 Transmission during Early Antiretroviral Therapy
T2 - Evaluation of Two HIV-1 Transmission Events in the HPTN 052 Prevention Study
AU - Ping, Li Hua
AU - Jabara, Cassandra B.
AU - Rodrigo, Allen G.
AU - Hudelson, Sarah E.
AU - Piwowar-Manning, Estelle
AU - Wang, Lei
AU - Eshleman, Susan H.
AU - Cohen, Myron S.
AU - Swanstrom, Ronald
PY - 2013/9/24
Y1 - 2013/9/24
N2 - In the HPTN 052 study, transmission between HIV-discordant couples was reduced by 96% when the HIV-infected partner received suppressive antiretroviral therapy (ART). We examined two transmission events where the newly infected partner was diagnosed after the HIV-infected partner (index) initiated therapy. We evaluated the sequence complexity of the viral populations and antibody reactivity in the newly infected partner to estimate the dates of transmission to the newly infected partners. In both cases, transmission most likely occurred significantly before HIV-1 diagnosis of the newly infected partner, and either just before the initiation of therapy or before viral replication was adequately suppressed by therapy of the index. This study further strengthens the conclusion about the efficacy of blocking transmission by treating the infected partner of discordant couples. However, this study does not rule out the potential for HIV-1 transmission to occur shortly after initiation of ART, and this should be recognized when antiretroviral therapy is used for HIV-1 prevention.
AB - In the HPTN 052 study, transmission between HIV-discordant couples was reduced by 96% when the HIV-infected partner received suppressive antiretroviral therapy (ART). We examined two transmission events where the newly infected partner was diagnosed after the HIV-infected partner (index) initiated therapy. We evaluated the sequence complexity of the viral populations and antibody reactivity in the newly infected partner to estimate the dates of transmission to the newly infected partners. In both cases, transmission most likely occurred significantly before HIV-1 diagnosis of the newly infected partner, and either just before the initiation of therapy or before viral replication was adequately suppressed by therapy of the index. This study further strengthens the conclusion about the efficacy of blocking transmission by treating the infected partner of discordant couples. However, this study does not rule out the potential for HIV-1 transmission to occur shortly after initiation of ART, and this should be recognized when antiretroviral therapy is used for HIV-1 prevention.
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U2 - 10.1371/journal.pone.0071557
DO - 10.1371/journal.pone.0071557
M3 - Article
C2 - 24086252
AN - SCOPUS:84884541971
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 9
M1 - e71557
ER -