TY - JOUR
T1 - HIV-1 transmission among injection drug users leads to novel recombinants circulating in Southern China
AU - Zhao, Ke
AU - Du, Juan
AU - Zheng, Wenwen
AU - Yu, Xiao Fang
N1 - Publisher Copyright:
© Copyright 2014, Mary Ann Liebert, Inc. 2014.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Injection drug use has been responsible for most HIV-1 transmission in Asia and has led to the generation and/or spreading of circulating recombinant CRF01AE, CRF07BC, and CRF08BC, which are currently the predominant HIV-1 strains in China. Monitoring HIV-1 transmissions among injection drug users (IDUs) still provides critical information on HIV-1 prevalence and control. In the present study, we detected three HIV-1 sequences, BH048/057/066, from IDUs in Beihai city, Guangxi province, all of which share an extremely complex mosaic recombination pattern. CRF01AE and CRF08BC contributed to the rise of new recombinants, which contain CRF08BC-derived env fragments with evidence of further evolution. Our data, combined with those of other studies, suggest that the BH048/057/066 recombinants represent early strains of a circulating recombinant form of HIV-1 in southern China. Information concerning such newly appearing variants is critical for both HIV-1 control and ongoing HIV-1 vaccine trials in Guangxi, China.
AB - Injection drug use has been responsible for most HIV-1 transmission in Asia and has led to the generation and/or spreading of circulating recombinant CRF01AE, CRF07BC, and CRF08BC, which are currently the predominant HIV-1 strains in China. Monitoring HIV-1 transmissions among injection drug users (IDUs) still provides critical information on HIV-1 prevalence and control. In the present study, we detected three HIV-1 sequences, BH048/057/066, from IDUs in Beihai city, Guangxi province, all of which share an extremely complex mosaic recombination pattern. CRF01AE and CRF08BC contributed to the rise of new recombinants, which contain CRF08BC-derived env fragments with evidence of further evolution. Our data, combined with those of other studies, suggest that the BH048/057/066 recombinants represent early strains of a circulating recombinant form of HIV-1 in southern China. Information concerning such newly appearing variants is critical for both HIV-1 control and ongoing HIV-1 vaccine trials in Guangxi, China.
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U2 - 10.1089/aid.2014.0036
DO - 10.1089/aid.2014.0036
M3 - Article
C2 - 25103676
AN - SCOPUS:84907550994
SN - 0889-2229
VL - 30
SP - 1006
EP - 1009
JO - AIDS research and human retroviruses
JF - AIDS research and human retroviruses
IS - 10
ER -