Abstract
HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-119 |
| Number of pages | 9 |
| Journal | Virology |
| Volume | 321 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 30 2004 |
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Keywords
- Helper CD4 T Cell
- Helper CD8 T Cells
- HIV
- HIV-1
- Human immunodeficiency virus
- Tc
- Tg
- Th
- Th1/Th2 cells
- Transgenic
ASJC Scopus subject areas
- Virology
- Infectious Diseases
Cite this
HIV-1 transgenic rats develop T cell abnormalities. / Reid, William; Abdelwahab, Sayed; Sadowska, Mariola; Huso, David; Neal, Ashley; Ahearn, Aaron; Bryant, Joseph; Gallo, Robert C.; Lewis, George K.; Reitz, Marvin.
In: Virology, Vol. 321, No. 1, 30.03.2004, p. 111-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV-1 transgenic rats develop T cell abnormalities
AU - Reid, William
AU - Abdelwahab, Sayed
AU - Sadowska, Mariola
AU - Huso, David
AU - Neal, Ashley
AU - Ahearn, Aaron
AU - Bryant, Joseph
AU - Gallo, Robert C.
AU - Lewis, George K.
AU - Reitz, Marvin
PY - 2004/3/30
Y1 - 2004/3/30
N2 - HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.
AB - HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.
KW - Helper CD4 T Cell
KW - Helper CD8 T Cells
KW - HIV
KW - HIV-1
KW - Human immunodeficiency virus
KW - Tc
KW - Tg
KW - Th
KW - Th1/Th2 cells
KW - Transgenic
UR - http://www.scopus.com/inward/record.url?scp=12144287178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12144287178&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2003.12.010
DO - 10.1016/j.virol.2003.12.010
M3 - Article
C2 - 15033570
AN - SCOPUS:12144287178
VL - 321
SP - 111
EP - 119
JO - Virology
JF - Virology
SN - 0042-6822
IS - 1
ER -