HIV-1 transgenic rats develop T cell abnormalities

William Reid, Sayed Abdelwahab, Mariola Sadowska, David Huso, Ashley Neal, Aaron Ahearn, Joseph Bryant, Robert C. Gallo, George K. Lewis, Marvin Reitz

Research output: Contribution to journalArticle

Abstract

HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalVirology
Volume321
Issue number1
DOIs
StatePublished - Mar 30 2004

Fingerprint

Transgenic Rats
HIV-1
T-Lymphocytes
Apoptosis
T-Lymphocyte Subsets
Transgenes
HIV Infections
Cell Proliferation
HIV
Antigens

Keywords

  • Helper CD4 T Cell
  • Helper CD8 T Cells
  • HIV
  • HIV-1
  • Human immunodeficiency virus
  • Tc
  • Tg
  • Th
  • Th1/Th2 cells
  • Transgenic

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Reid, W., Abdelwahab, S., Sadowska, M., Huso, D., Neal, A., Ahearn, A., ... Reitz, M. (2004). HIV-1 transgenic rats develop T cell abnormalities. Virology, 321(1), 111-119. https://doi.org/10.1016/j.virol.2003.12.010

HIV-1 transgenic rats develop T cell abnormalities. / Reid, William; Abdelwahab, Sayed; Sadowska, Mariola; Huso, David; Neal, Ashley; Ahearn, Aaron; Bryant, Joseph; Gallo, Robert C.; Lewis, George K.; Reitz, Marvin.

In: Virology, Vol. 321, No. 1, 30.03.2004, p. 111-119.

Research output: Contribution to journalArticle

Reid, W, Abdelwahab, S, Sadowska, M, Huso, D, Neal, A, Ahearn, A, Bryant, J, Gallo, RC, Lewis, GK & Reitz, M 2004, 'HIV-1 transgenic rats develop T cell abnormalities', Virology, vol. 321, no. 1, pp. 111-119. https://doi.org/10.1016/j.virol.2003.12.010
Reid W, Abdelwahab S, Sadowska M, Huso D, Neal A, Ahearn A et al. HIV-1 transgenic rats develop T cell abnormalities. Virology. 2004 Mar 30;321(1):111-119. https://doi.org/10.1016/j.virol.2003.12.010
Reid, William ; Abdelwahab, Sayed ; Sadowska, Mariola ; Huso, David ; Neal, Ashley ; Ahearn, Aaron ; Bryant, Joseph ; Gallo, Robert C. ; Lewis, George K. ; Reitz, Marvin. / HIV-1 transgenic rats develop T cell abnormalities. In: Virology. 2004 ; Vol. 321, No. 1. pp. 111-119.
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