HIV-1 transgenic rats develop T cell abnormalities

William Reid; Sayed Abdelwahab; Mariola Sadowska; David Huso; Ashley Neal; Aaron Ahearn; Joseph Bryant; Robert C. Gallo; George K. Lewis; Marvin Reitz

doi:10.1016/j.virol.2003.12.010

HIV-1 transgenic rats develop T cell abnormalities

William Reid, Sayed Abdelwahab, Mariola Sadowska, David Huso, Ashley Neal, Aaron Ahearn, Joseph Bryant, Robert C. Gallo, George K. Lewis, Marvin Reitz

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4⁺ and CD8⁺ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4⁺ and CD8⁺ effector/memory (CD45RC^-CD62L^-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC⁺CD62L⁺) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.

Original language	English (US)
Pages (from-to)	111-119
Number of pages	9
Journal	Virology
Volume	321
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2003.12.010
State	Published - Mar 30 2004
Externally published	Yes

Keywords

HIV
HIV-1
Helper CD4 T Cell
Helper CD8 T Cells
Human immunodeficiency virus
Tc
Tg
Th
Th1/Th2 cells
Transgenic

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2003.12.010

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title = "HIV-1 transgenic rats develop T cell abnormalities",

abstract = "HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the na{\"i}ve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.",

keywords = "HIV, HIV-1, Helper CD4 T Cell, Helper CD8 T Cells, Human immunodeficiency virus, Tc, Tg, Th, Th1/Th2 cells, Transgenic",

author = "William Reid and Sayed Abdelwahab and Mariola Sadowska and David Huso and Ashley Neal and Aaron Ahearn and Joseph Bryant and Gallo, {Robert C.} and Lewis, {George K.} and Marvin Reitz",

note = "Funding Information: This work was supported by Public Health Service Grant 1K08 AI01792. We thank Odell Jones and Karen Nichols for their help with the animal studies and Peter O'Driscoll for his assistance with the statistics.",

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doi = "10.1016/j.virol.2003.12.010",

language = "English (US)",

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AU - Reid, William

AU - Abdelwahab, Sayed

AU - Sadowska, Mariola

AU - Huso, David

AU - Neal, Ashley

AU - Ahearn, Aaron

AU - Bryant, Joseph

AU - Gallo, Robert C.

AU - Lewis, George K.

AU - Reitz, Marvin

N1 - Funding Information: This work was supported by Public Health Service Grant 1K08 AI01792. We thank Odell Jones and Karen Nichols for their help with the animal studies and Peter O'Driscoll for his assistance with the statistics.

PY - 2004/3/30

Y1 - 2004/3/30

N2 - HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.

AB - HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.

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KW - HIV-1

KW - Helper CD4 T Cell

KW - Helper CD8 T Cells

KW - Human immunodeficiency virus

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KW - Th

KW - Th1/Th2 cells

KW - Transgenic

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HIV-1 transgenic rats develop T cell abnormalities

Abstract

Keywords

ASJC Scopus subject areas

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