HIV-1 transgenic rats develop T cell abnormalities

William Reid, Sayed Abdelwahab, Mariola Sadowska, David Huso, Ashley Neal, Aaron Ahearn, Joseph Bryant, Robert C. Gallo, George K. Lewis, Marvin Reitz

Research output: Contribution to journalArticle

Abstract

HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalVirology
Volume321
Issue number1
DOIs
StatePublished - Mar 30 2004

Keywords

  • HIV
  • HIV-1
  • Helper CD4 T Cell
  • Helper CD8 T Cells
  • Human immunodeficiency virus
  • Tc
  • Tg
  • Th
  • Th1/Th2 cells
  • Transgenic

ASJC Scopus subject areas

  • Virology

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