Abstract
HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC-CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.
Original language | English (US) |
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Pages (from-to) | 111-119 |
Number of pages | 9 |
Journal | Virology |
Volume | 321 |
Issue number | 1 |
DOIs | |
State | Published - Mar 30 2004 |
Externally published | Yes |
Keywords
- HIV
- HIV-1
- Helper CD4 T Cell
- Helper CD8 T Cells
- Human immunodeficiency virus
- Tc
- Tg
- Th
- Th1/Th2 cells
- Transgenic
ASJC Scopus subject areas
- Virology