HIV-1 Subtype Distribution and Diversity over 18 Years in Rakai, Uganda

Susanna L. Lamers; Rebecca Rose; Sissy Cross; Christopher W. Rodriguez; Andrew D. Redd; Thomas C. Quinn; David Serwadda; Joseph Kagaayi; Godfrey Kigozi; Ronald Galiwango; Ronald H. Gray; M. Kate Grabowski; Oliver Laeyendecker

doi:10.1089/aid.2020.0062

HIV-1 Subtype Distribution and Diversity over 18 Years in Rakai, Uganda

Susanna L. Lamers, Rebecca Rose, Sissy Cross, Christopher W. Rodriguez, Andrew D. Redd, Thomas C. Quinn, David Serwadda, Joseph Kagaayi, Godfrey Kigozi, Ronald Galiwango, Ronald H. Gray, M. Kate Grabowski, Oliver Laeyendecker

Research output: Contribution to journal › Article › peer-review

Abstract

The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2008-2009, which were compared with a new survey round from 2011 to 2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p <.01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.

Original language	English (US)
Pages (from-to)	522-526
Number of pages	5
Journal	AIDS research and human retroviruses
Volume	36
Issue number	6
DOIs	https://doi.org/10.1089/aid.2020.0062
State	Published - Jun 1 2020

Keywords

Uganda
sequence diversity
subtype change

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

Access to Document

10.1089/aid.2020.0062

Cite this

@article{f0d694e6f9404726a76c08c6bb83707f,

title = "HIV-1 Subtype Distribution and Diversity over 18 Years in Rakai, Uganda",

abstract = "The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2008-2009, which were compared with a new survey round from 2011 to 2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p <.01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.",

keywords = "Uganda, sequence diversity, subtype change",

author = "Lamers, {Susanna L.} and Rebecca Rose and Sissy Cross and Rodriguez, {Christopher W.} and Redd, {Andrew D.} and Quinn, {Thomas C.} and David Serwadda and Joseph Kagaayi and Godfrey Kigozi and Ronald Galiwango and Gray, {Ronald H.} and Grabowski, {M. Kate} and Oliver Laeyendecker",

year = "2020",

month = jun,

day = "1",

doi = "10.1089/aid.2020.0062",

language = "English (US)",

volume = "36",

pages = "522--526",

journal = "AIDS research and human retroviruses",

issn = "0889-2229",

publisher = "Mary Ann Liebert Inc.",

number = "6",

}

TY - JOUR

T1 - HIV-1 Subtype Distribution and Diversity over 18 Years in Rakai, Uganda

AU - Lamers, Susanna L.

AU - Rose, Rebecca

AU - Cross, Sissy

AU - Rodriguez, Christopher W.

AU - Redd, Andrew D.

AU - Quinn, Thomas C.

AU - Serwadda, David

AU - Kagaayi, Joseph

AU - Kigozi, Godfrey

AU - Galiwango, Ronald

AU - Gray, Ronald H.

AU - Grabowski, M. Kate

AU - Laeyendecker, Oliver

PY - 2020/6/1

Y1 - 2020/6/1

N2 - The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2008-2009, which were compared with a new survey round from 2011 to 2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p <.01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.

AB - The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2008-2009, which were compared with a new survey round from 2011 to 2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p <.01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.

KW - Uganda

KW - sequence diversity

KW - subtype change

UR - http://www.scopus.com/inward/record.url?scp=85085904055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85085904055&partnerID=8YFLogxK

U2 - 10.1089/aid.2020.0062

DO - 10.1089/aid.2020.0062

M3 - Article

C2 - 32281387

AN - SCOPUS:85085904055

SN - 0889-2229

VL - 36

SP - 522

EP - 526

JO - AIDS research and human retroviruses

JF - AIDS research and human retroviruses

IS - 6

ER -

HIV-1 Subtype Distribution and Diversity over 18 Years in Rakai, Uganda

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this