HIV-1 Subtype Distribution and Diversity over 18 Years in Rakai, Uganda

Susanna L. Lamers, Rebecca Rose, Sissy Cross, Christopher W. Rodriguez, Andrew D. Redd, Thomas C. Quinn, David Serwadda, Joseph Kagaayi, Godfrey Kigozi, Ronald Galiwango, Ronald H. Gray, M. Kate Grabowski, Oliver Laeyendecker

Research output: Contribution to journalArticle

Abstract

The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2008-2009, which were compared with a new survey round from 2011 to 2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p <.01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.

Original languageEnglish (US)
Pages (from-to)522-526
Number of pages5
JournalAIDS research and human retroviruses
Volume36
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • Uganda
  • sequence diversity
  • subtype change

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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