HIV-1 risk and vaccine acceptability in the Ugandan military

D. L. Hom, J. L. Johnson, P. Mugyenyi, R. Byaruhanga, C. Kityo, A. Louglin, G. M. Svilar, M. Vjecha, R. D. Mugerwa, J. J. Ellner

Research output: Contribution to journalArticle

Abstract

Between July and October 1993, 570 19- to 22-year-old volunteers were screened for HIV-1, with a resulting seroprevalence rate of 18.3% (95% CI: 14.0%. 22.6%). A cohort of 249 HIV-1-noninfected military recruits in the Ugandan Peoples' Defense Forces was followed prospectively for up to 18 months to document rates of HIV-1 seroprevalence, seroconversion, and knowledge and attitudes related to vaccine acceptability. The HIV-1 seroincidence rate was 3.56 per 100 person-years (95% CI: 1.49, 5.62) over 309 person-years of observation. At the 3- and 12-month visits, subjects were interviewed on issues of acceptance and knowledge about vaccines, including anti-HIV vaccines in particular. More than 90% believe that HIV vaccines will not cause HIV infection, and if offered, 88% report that they would take the vaccine if they were not already infected. Nonvaccine prevention methods were considered less reliable; monogamy and condom use were considered effective by only 33.5% and 69.3% of the cohort respectively. After completing the vaccine acceptability questionnaire at the 12-month visit, subjects were offered an approved polyvalent meningococcal vaccine as an indicator of general vaccine acceptance. All subjects reported receiving at least one previous vaccination, and 95% willingly accepted the meningococcal vaccination. The Ugandan military is a stable population at substantial risk for HIV-1 infection and may be a suitable population for vaccine efficacy trials.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume15
Issue number5
StatePublished - Aug 15 1997
Externally publishedYes

Fingerprint

AIDS Vaccines
HIV-1
Vaccines
HIV Infections
Vaccination
HIV Seroprevalence
Meningococcal Vaccines
Seroepidemiologic Studies
Condoms
Population Dynamics
Volunteers
Observation
Population

Keywords

  • Africa Uganda
  • Anti-HIV vaccine
  • HIV-1
  • Seroincidence
  • Seroprevalence
  • Vaccine acceptability

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Hom, D. L., Johnson, J. L., Mugyenyi, P., Byaruhanga, R., Kityo, C., Louglin, A., ... Ellner, J. J. (1997). HIV-1 risk and vaccine acceptability in the Ugandan military. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 15(5), 375-380.

HIV-1 risk and vaccine acceptability in the Ugandan military. / Hom, D. L.; Johnson, J. L.; Mugyenyi, P.; Byaruhanga, R.; Kityo, C.; Louglin, A.; Svilar, G. M.; Vjecha, M.; Mugerwa, R. D.; Ellner, J. J.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 15, No. 5, 15.08.1997, p. 375-380.

Research output: Contribution to journalArticle

Hom, DL, Johnson, JL, Mugyenyi, P, Byaruhanga, R, Kityo, C, Louglin, A, Svilar, GM, Vjecha, M, Mugerwa, RD & Ellner, JJ 1997, 'HIV-1 risk and vaccine acceptability in the Ugandan military', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 15, no. 5, pp. 375-380.
Hom DL, Johnson JL, Mugyenyi P, Byaruhanga R, Kityo C, Louglin A et al. HIV-1 risk and vaccine acceptability in the Ugandan military. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1997 Aug 15;15(5):375-380.
Hom, D. L. ; Johnson, J. L. ; Mugyenyi, P. ; Byaruhanga, R. ; Kityo, C. ; Louglin, A. ; Svilar, G. M. ; Vjecha, M. ; Mugerwa, R. D. ; Ellner, J. J. / HIV-1 risk and vaccine acceptability in the Ugandan military. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1997 ; Vol. 15, No. 5. pp. 375-380.
@article{678ea2f0f6c64c378a25eb76acc21728,
title = "HIV-1 risk and vaccine acceptability in the Ugandan military",
abstract = "Between July and October 1993, 570 19- to 22-year-old volunteers were screened for HIV-1, with a resulting seroprevalence rate of 18.3{\%} (95{\%} CI: 14.0{\%}. 22.6{\%}). A cohort of 249 HIV-1-noninfected military recruits in the Ugandan Peoples' Defense Forces was followed prospectively for up to 18 months to document rates of HIV-1 seroprevalence, seroconversion, and knowledge and attitudes related to vaccine acceptability. The HIV-1 seroincidence rate was 3.56 per 100 person-years (95{\%} CI: 1.49, 5.62) over 309 person-years of observation. At the 3- and 12-month visits, subjects were interviewed on issues of acceptance and knowledge about vaccines, including anti-HIV vaccines in particular. More than 90{\%} believe that HIV vaccines will not cause HIV infection, and if offered, 88{\%} report that they would take the vaccine if they were not already infected. Nonvaccine prevention methods were considered less reliable; monogamy and condom use were considered effective by only 33.5{\%} and 69.3{\%} of the cohort respectively. After completing the vaccine acceptability questionnaire at the 12-month visit, subjects were offered an approved polyvalent meningococcal vaccine as an indicator of general vaccine acceptance. All subjects reported receiving at least one previous vaccination, and 95{\%} willingly accepted the meningococcal vaccination. The Ugandan military is a stable population at substantial risk for HIV-1 infection and may be a suitable population for vaccine efficacy trials.",
keywords = "Africa Uganda, Anti-HIV vaccine, HIV-1, Seroincidence, Seroprevalence, Vaccine acceptability",
author = "Hom, {D. L.} and Johnson, {J. L.} and P. Mugyenyi and R. Byaruhanga and C. Kityo and A. Louglin and Svilar, {G. M.} and M. Vjecha and Mugerwa, {R. D.} and Ellner, {J. J.}",
year = "1997",
month = "8",
day = "15",
language = "English (US)",
volume = "15",
pages = "375--380",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - HIV-1 risk and vaccine acceptability in the Ugandan military

AU - Hom, D. L.

AU - Johnson, J. L.

AU - Mugyenyi, P.

AU - Byaruhanga, R.

AU - Kityo, C.

AU - Louglin, A.

AU - Svilar, G. M.

AU - Vjecha, M.

AU - Mugerwa, R. D.

AU - Ellner, J. J.

PY - 1997/8/15

Y1 - 1997/8/15

N2 - Between July and October 1993, 570 19- to 22-year-old volunteers were screened for HIV-1, with a resulting seroprevalence rate of 18.3% (95% CI: 14.0%. 22.6%). A cohort of 249 HIV-1-noninfected military recruits in the Ugandan Peoples' Defense Forces was followed prospectively for up to 18 months to document rates of HIV-1 seroprevalence, seroconversion, and knowledge and attitudes related to vaccine acceptability. The HIV-1 seroincidence rate was 3.56 per 100 person-years (95% CI: 1.49, 5.62) over 309 person-years of observation. At the 3- and 12-month visits, subjects were interviewed on issues of acceptance and knowledge about vaccines, including anti-HIV vaccines in particular. More than 90% believe that HIV vaccines will not cause HIV infection, and if offered, 88% report that they would take the vaccine if they were not already infected. Nonvaccine prevention methods were considered less reliable; monogamy and condom use were considered effective by only 33.5% and 69.3% of the cohort respectively. After completing the vaccine acceptability questionnaire at the 12-month visit, subjects were offered an approved polyvalent meningococcal vaccine as an indicator of general vaccine acceptance. All subjects reported receiving at least one previous vaccination, and 95% willingly accepted the meningococcal vaccination. The Ugandan military is a stable population at substantial risk for HIV-1 infection and may be a suitable population for vaccine efficacy trials.

AB - Between July and October 1993, 570 19- to 22-year-old volunteers were screened for HIV-1, with a resulting seroprevalence rate of 18.3% (95% CI: 14.0%. 22.6%). A cohort of 249 HIV-1-noninfected military recruits in the Ugandan Peoples' Defense Forces was followed prospectively for up to 18 months to document rates of HIV-1 seroprevalence, seroconversion, and knowledge and attitudes related to vaccine acceptability. The HIV-1 seroincidence rate was 3.56 per 100 person-years (95% CI: 1.49, 5.62) over 309 person-years of observation. At the 3- and 12-month visits, subjects were interviewed on issues of acceptance and knowledge about vaccines, including anti-HIV vaccines in particular. More than 90% believe that HIV vaccines will not cause HIV infection, and if offered, 88% report that they would take the vaccine if they were not already infected. Nonvaccine prevention methods were considered less reliable; monogamy and condom use were considered effective by only 33.5% and 69.3% of the cohort respectively. After completing the vaccine acceptability questionnaire at the 12-month visit, subjects were offered an approved polyvalent meningococcal vaccine as an indicator of general vaccine acceptance. All subjects reported receiving at least one previous vaccination, and 95% willingly accepted the meningococcal vaccination. The Ugandan military is a stable population at substantial risk for HIV-1 infection and may be a suitable population for vaccine efficacy trials.

KW - Africa Uganda

KW - Anti-HIV vaccine

KW - HIV-1

KW - Seroincidence

KW - Seroprevalence

KW - Vaccine acceptability

UR - http://www.scopus.com/inward/record.url?scp=12644263397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12644263397&partnerID=8YFLogxK

M3 - Article

C2 - 9342258

AN - SCOPUS:12644263397

VL - 15

SP - 375

EP - 380

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 5

ER -