HIV-1 prevalence and herpes simplex virus 2, hepatitis C virus, and hepatitis B virus infections among male workers at a sugar estate in Malawi

Siobhan Sutcliffe, Taha E. Taha, Newton I. Kumwenda, Ellen Taylor, George N. Liomba

Research output: Contribution to journalArticlepeer-review

Abstract

HIV-1 prevalence is approximately 23% among men working at a sugar estate in Malawi. Given the scale of the HIV epidemic in this country, it is important to determine possible cofactors of infection. The authors investigated associations between HIV-1 prevalence and herpes simplex virus 2 (HSV-2), hepatitis C virus (HCV), and hepatitis B virus (HBV) infections (indicated by anti-HSV-2, anti-HCV and HBsAg positivity, respectively) in a nested case-control study of 279 HIV-positive and 280 HIV-negative male workers. The prevalence of HSV-2 infection was 88.1% among HIV-positive persons and 64.3% among HIV-negative control subjects (p < .01). This difference persisted after adjusting for sexual behavior and history of sexually transmitted diseases (OR = 4.12; 95% CI, 2.21-7.68). The prevalence of HCV seropositivity was 12.7% among HIV-positive persons and 10.0% among control subjects (p = .31), whereas that of HBV infection was 16.9% among HIV-positive persons and 14.4% among control subjects (p = .46). HSV-2 infection is significantly associated with prevalent HIV-1 infection in this population. Therefore, preventive measures for HSV-2 and HIV infection should be emphasized.

Original languageEnglish (US)
Pages (from-to)90-97
Number of pages8
JournalJournal of acquired immune deficiency syndromes
Volume31
Issue number1
DOIs
StatePublished - Sep 1 2002

Keywords

  • HIV
  • Hepatitis B virus
  • Hepatitis C virus
  • Herpes simplex virus 2
  • Malawi

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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