TY - JOUR
T1 - HIV-1 infection in women is associated with severe nutritional deficiencies
AU - Baum, Marianna K.
AU - Shor-Posner, Gail
AU - Zhang, Guoyan
AU - Lai, Hong
AU - Quesada, Jose A.
AU - Campa, Adriana
AU - Jose-Burbano, Maria
AU - Fletcher, Mary Ann
AU - Sauberlich, Howerde
AU - Page, J. Bryan
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1997/12/1
Y1 - 1997/12/1
N2 - Nutritional deficiencies may contribute to immune dysregulation, and have been shown to be sensitive markers of HIV-1 disease progression. Only limited information exists, however, regarding the nutritional profile of HIV-1-seropositive drug abusers. Immune and nutritional measurements were obtained in a subsample of 125 subjects from a larger cohort of drug users being followed for HIV-1 infection and cofactors of disease progression. Nutritional deficiencies, particularly vitamins A, E, and zinc, were widespread with up to 86% of the drug users exhibiting at least one nutritional alteration. Although immune parameters (CD4 count, CD8 count, β2-microglobulin) were similar in the HIV-1-infected men and women, women had significantly poorer overall nutritional status, as measured by plasma proteins, which are considered to be sensitive markers of malnutrition. A comparison of individuals with advanced disease (CD4 count <200/mm3) revealed significantly lower levels of plasma prealbumin (p < .01), selenium, (p < .05), and greater deficiency of vitamins A (p < .01) and E (p < .05) in women than in men. The greater severity of nutritional deficiencies noted in HIV-1-infected women may be an important determinant of disease progression and survival.
AB - Nutritional deficiencies may contribute to immune dysregulation, and have been shown to be sensitive markers of HIV-1 disease progression. Only limited information exists, however, regarding the nutritional profile of HIV-1-seropositive drug abusers. Immune and nutritional measurements were obtained in a subsample of 125 subjects from a larger cohort of drug users being followed for HIV-1 infection and cofactors of disease progression. Nutritional deficiencies, particularly vitamins A, E, and zinc, were widespread with up to 86% of the drug users exhibiting at least one nutritional alteration. Although immune parameters (CD4 count, CD8 count, β2-microglobulin) were similar in the HIV-1-infected men and women, women had significantly poorer overall nutritional status, as measured by plasma proteins, which are considered to be sensitive markers of malnutrition. A comparison of individuals with advanced disease (CD4 count <200/mm3) revealed significantly lower levels of plasma prealbumin (p < .01), selenium, (p < .05), and greater deficiency of vitamins A (p < .01) and E (p < .05) in women than in men. The greater severity of nutritional deficiencies noted in HIV-1-infected women may be an important determinant of disease progression and survival.
KW - Drug users
KW - HIV-1-positive men
KW - HIV-1-positive women
KW - Nutritional status
UR - http://www.scopus.com/inward/record.url?scp=12644298657&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12644298657&partnerID=8YFLogxK
U2 - 10.1097/00042560-199712010-00008
DO - 10.1097/00042560-199712010-00008
M3 - Article
C2 - 9402074
AN - SCOPUS:12644298657
SN - 1077-9450
VL - 16
SP - 272
EP - 278
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
IS - 4
ER -