HIV-1-induced depletion of CD4+ T cells in the gut: Mechanism and therapeutic implications

Amanda Chase, Yan Zhou, Robert F. Siliciano

Research output: Contribution to journalShort surveypeer-review


The mechanism of CD4+ T-cell depletion remains a central unresolved issue in AIDS research. Recent studies have examined the massive depletion of CD4+ T cells observed in macaque models of acute HIV infection. A key question is whether the observed CD4+ T-cell death is due to direct consequences of viral infection and to indirect mechanisms including increased expression of mediators of T-cell apoptosis. The therapeutic implications of the early CD4+ T-cell loss are discussed.

Original languageEnglish (US)
Pages (from-to)4-7
Number of pages4
JournalTrends in Pharmacological Sciences
Issue number1
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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