HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses

S. H. Lewis, H. E. Fox, S. H. Lewis, S. H. Lewis, C. Reynolds-Kohler, J. A. Nelson

Research output: Contribution to journalArticle

Abstract

AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalThe Lancet
Volume335
Issue number8689
DOIs
StatePublished - Mar 10 1990
Externally publishedYes

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HIV-1
Fetus
Nucleic Acids
Gestational Age
In Situ Hybridization
Blood Cells
Acquired Immunodeficiency Syndrome
Leukocytes
Western Blotting
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Mothers
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lewis, S. H., Fox, H. E., Lewis, S. H., Lewis, S. H., Reynolds-Kohler, C., & Nelson, J. A. (1990). HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses. The Lancet, 335(8689), 565-568. https://doi.org/10.1016/0140-6736(90)90349-A

HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses. / Lewis, S. H.; Fox, H. E.; Lewis, S. H.; Lewis, S. H.; Reynolds-Kohler, C.; Nelson, J. A.

In: The Lancet, Vol. 335, No. 8689, 10.03.1990, p. 565-568.

Research output: Contribution to journalArticle

Lewis, SH, Fox, HE, Lewis, SH, Lewis, SH, Reynolds-Kohler, C & Nelson, JA 1990, 'HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses', The Lancet, vol. 335, no. 8689, pp. 565-568. https://doi.org/10.1016/0140-6736(90)90349-A
Lewis, S. H. ; Fox, H. E. ; Lewis, S. H. ; Lewis, S. H. ; Reynolds-Kohler, C. ; Nelson, J. A. / HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses. In: The Lancet. 1990 ; Vol. 335, No. 8689. pp. 565-568.
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