TY - JOUR
T1 - HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE
AU - Tovanabutra, Sodsai
AU - De Souza, Mark
AU - Sittisombut, Nopporn
AU - Sriplienchan, Somchai
AU - Ketsararat, Vidhaya
AU - Birx, Deborah L.
AU - Khamboonrueng, Chirasak
AU - Nelson, Kenrad E.
AU - McCutchan, Francine E.
AU - Robb, Merlin L.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/5
Y1 - 2007/5
N2 - Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in different compartments in mothers with high CD4 cell counts. Infant viruses were almost distinct, but phylogenetically related, to maternal viruses, mostly from the maternal PBMC compartment, reflecting the frequent transmission of HIV-1 from maternal cells rather than free viruses.
AB - Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in different compartments in mothers with high CD4 cell counts. Infant viruses were almost distinct, but phylogenetically related, to maternal viruses, mostly from the maternal PBMC compartment, reflecting the frequent transmission of HIV-1 from maternal cells rather than free viruses.
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U2 - 10.1097/QAD.0b013e32810c8cf3
DO - 10.1097/QAD.0b013e32810c8cf3
M3 - Article
C2 - 17457103
AN - SCOPUS:34247603948
SN - 0269-9370
VL - 21
SP - 1050
EP - 1053
JO - AIDS
JF - AIDS
IS - 8
ER -