HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia

Christine M. Durand, Karen A. O'Connell, Linda Apuzzo, Susan J. Langan, Hejab Imteyaz, Aima A. Ahonkhai, Christina M. Ceccato, Thomas M. Williams, Joseph B. Margolick, Joel N. Blankson

Research output: Contribution to journalArticlepeer-review

Abstract

We studied viral evolution in five human leukocyte antigen (HLA)-B*57 patients recently infected with HIV-1. Escape mutations in HLA-B*57- restricted Gag epitopes were present at study entry in all patients, but were not associated with significant increases in viremia. Conversely, no new escape mutations in HLA-B*57-restricted epitopes or known compensatory mutations were detected in patients who experienced significant increases in viremia. Thus, the development of escape mutations alone does not determine virologic outcome in recently infected HLA-B*57 patients.

Original languageEnglish (US)
Pages (from-to)2405-2408
Number of pages4
JournalAIDS
Volume24
Issue number15
DOIs
StatePublished - Sep 24 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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