Abstract
We describe cryo-electron microscopic studies of the interaction between the ectodomain of the trimeric HIV-1 envelope glycoprotein (Env) and Z13e1, a broadly neutralizing antibody that targets the membrane-proximal external region (MPER) of the gp41 subunit. We show that Z13e1-bound Env displays an open quaternary conformation similar to the CD4-bound conformation. Our results support the idea that MPER-directed antibodies, such as Z13e1, block viral entry by interacting with Env at a step after CD4 activation.
Original language | English (US) |
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Pages (from-to) | 7191-7196 |
Number of pages | 6 |
Journal | Journal of Virology |
Volume | 87 |
Issue number | 12 |
DOIs | |
State | Published - Jun 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology
- Virology