HIV-1 DNA shedding in genital ulcers and its associated risk factors in Pune, India

D. A. Gadkari, T. C. Quinn, R. R. Gangakhedkar, S. M. Mehendale, A. D. Divekar, A. R. Risbud, K. Chan-Tack, M. Shepherd, C. Gaydos, R. C. Bollinger

Research output: Contribution to journalArticle

Abstract

HIV infection status was determined in 302 consecutive patients with genital ulcer disease (GUD) presenting to two sexually transmitted disease (STD) clinics in Pune, India. Of the 71 (24%) individuals with HIV infection, 67 (94%) were HIV antibody-positive, and 4 (6%) were HIV antibody-negative but p24 antigen-positive at the time of presentation. HIV-1 DNA was detected in 24 (34%) specimens. The genital ulcers of all four acutely infected p24- antigenemic subjects were HIV-1 DNA-positive by polymerase chain reaction (PCR) assay, compared with 20 of 67 (30%) seropositive patients (p = .01). Presence of chancroid, GUD symptoms for > 10 days, and concurrent diagnosis of cervicitis or urethritis were significantly associated risk factors for HIV-1 DNA shedding in ulcers. Early GUD diagnosis and aggressive treatment of HIV-infected patients may significantly reduce secondary transmission of HIV to other sex partners.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume18
Issue number3
DOIs
StatePublished - Jul 1 1998

Keywords

  • Genital ulcer disease (GUD)
  • HIV-1 shedding
  • India
  • Polymerase chain reaction (PCR)
  • Sexually transmitted diseases (STD)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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