Abstract
HIV infection status was determined in 302 consecutive patients with genital ulcer disease (GUD) presenting to two sexually transmitted disease (STD) clinics in Pune, India. Of the 71 (24%) individuals with HIV infection, 67 (94%) were HIV antibody-positive, and 4 (6%) were HIV antibody-negative but p24 antigen-positive at the time of presentation. HIV-1 DNA was detected in 24 (34%) specimens. The genital ulcers of all four acutely infected p24- antigenemic subjects were HIV-1 DNA-positive by polymerase chain reaction (PCR) assay, compared with 20 of 67 (30%) seropositive patients (p = .01). Presence of chancroid, GUD symptoms for > 10 days, and concurrent diagnosis of cervicitis or urethritis were significantly associated risk factors for HIV-1 DNA shedding in ulcers. Early GUD diagnosis and aggressive treatment of HIV-infected patients may significantly reduce secondary transmission of HIV to other sex partners.
Original language | English (US) |
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Pages (from-to) | 277-281 |
Number of pages | 5 |
Journal | Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1 1998 |
Externally published | Yes |
Keywords
- Genital ulcer disease (GUD)
- HIV-1 shedding
- India
- Polymerase chain reaction (PCR)
- Sexually transmitted diseases (STD)
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Virology