HIV-1 DNA based vaccine induces a CD8 mediated cross-clade CTL response.

J. D. Boyer, M. Chattergoon, A. Shah, R. Ginsberg, R. R. MacGregor, D. B. Weiner

Research output: Contribution to journalArticle

Abstract

Novel approaches for the generation of more effective vaccines for HIV-1 are of significant importance. In this report we analyse the immunogenicity and efficacy of a DNA vaccination approach in a chimpanzee model system. Three chimpanzees were vaccinated with DNA constructs which express the env, rev, gag and pol proteins. These animals developed specific cellular responses to these proteins, although the nature of the responses varied among the animals. We demonstrated that DNA vaccination led to a CD8 mediated killing of targets expressing the homologous clade B envelope as well as targets expressing heterologous clade E envelope. In addition seronegative individuals have been inoculated with a DNA construct which expresses the env, rev proteins. These studies serve as an important benchmark for the use of DNA vaccine technology for the production of protective immune responses.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalDevelopments in biological standardization
Volume95
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Drug Discovery
  • Public Health, Environmental and Occupational Health

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  • Cite this

    Boyer, J. D., Chattergoon, M., Shah, A., Ginsberg, R., MacGregor, R. R., & Weiner, D. B. (1998). HIV-1 DNA based vaccine induces a CD8 mediated cross-clade CTL response. Developments in biological standardization, 95, 147-153.