HIV-1 and the blood-brain barrier

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Central nervous system (CNS) dysfunction represents a common and serious manifestation of HIV-1 infection. Approximately one-third of adults and one-half of children with AIDS have neurological complications, which are directly attributable to infection of the CNS by HIV-1 (1,2). Neurological manifestations of primary HIV-1 infection are associated with an accelerated progression of disease (3), and the presence of progressive encephalopathy has been correlated with poor outcome (4). The exact timing of HIV-1 infection of the CNS is unknown. Several studies have shown entry of HIV-1 into the CNS early after infection (5-13); however, how HIV-1 enters the CNS is unclear. HIV-1-associated neurological dysfunction occurs in the absence of opportunistic infections, implying the limited role of coinfection in the pathogenesis of HIV-1 encephalopathy. In addition, neurological impairment has been shown to be the first signs of HIV-1-related diseases in some cases (6,9).

Original languageEnglish (US)
Title of host publicationAIDS and Heart Disease
PublisherCRC Press
Pages46-61
Number of pages16
ISBN (Electronic)9780203021897
ISBN (Print)9780824741150
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'HIV-1 and the blood-brain barrier'. Together they form a unique fingerprint.

  • Cite this

    Kim, K. S. (2004). HIV-1 and the blood-brain barrier. In AIDS and Heart Disease (pp. 46-61). CRC Press.