History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China

H. Dean HosgoodIII, Robert S. Chapman, Xingzhou He, Wei Hu, Linwei Tian, Larry Z. Liu, Hong Chen Lai, Wei Chen, Nathaniel Rothman, Qing Lan

Research output: Contribution to journalArticle

Abstract

History of chronic lung diseases and household coal use for heating and cooking are established risk factors of lung cancer; however, few studies have been able to explore these risk factors simultaneously. Xuanwei, China, has some of the highest rates of lung cancer in China and most residents experience substantial in-home coal smoke exposures. Using a population-based case-control study of 498 lung cancer cases and 498 age-matched controls, we evaluated the risk of lung cancer in relation to coal smoke exposure and history of chronic lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, tuberculosis (TB), chronic bronchitis, and emphysema. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression adjusting for potential confounders. We observed an increased risk of lung cancer with history of any chronic lung disease among males (OR. = 14.2; 95%CI. = 4.3-46.9), females (OR. = 2.6; 95%CI. = 1.1-6.3), smokers (OR. = 12.7; 95%CI. = 3.5-45.8), and nonsmokers (OR. = 2.6; 95%CI. = 1.1-6.4). Specifically, TB (OR. = 83.7; 95%CI. = 11.0-634.7), COPD (OR. = 3.2; 95%CI. = 1.7-6.0), and emphysema and chronic bronchitis (OR. = 3.3; 95%CI. = 1.7-6.4) were associated with increased risks. These findings suggest that history of chronic lung diseases may also increase risk of lung cancer in populations with indoor coal smoke exposures.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalLung Cancer
Volume81
Issue number3
DOIs
StatePublished - Sep 2013

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Lung Diseases
China
Lung Neoplasms
Odds Ratio
Confidence Intervals
Coal
Population
Chronic Disease
Smoke
Chronic Bronchitis
Emphysema
Chronic Obstructive Pulmonary Disease
Tuberculosis
Cooking
Heating
Case-Control Studies
Asthma
Logistic Models

Keywords

  • China
  • Chronic lung disease
  • Lung cancer
  • Never smoking
  • Xuanwei

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China. / HosgoodIII, H. Dean; Chapman, Robert S.; He, Xingzhou; Hu, Wei; Tian, Linwei; Liu, Larry Z.; Lai, Hong Chen; Chen, Wei; Rothman, Nathaniel; Lan, Qing.

In: Lung Cancer, Vol. 81, No. 3, 09.2013, p. 343-346.

Research output: Contribution to journalArticle

HosgoodIII, HD, Chapman, RS, He, X, Hu, W, Tian, L, Liu, LZ, Lai, HC, Chen, W, Rothman, N & Lan, Q 2013, 'History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China', Lung Cancer, vol. 81, no. 3, pp. 343-346. https://doi.org/10.1016/j.lungcan.2013.06.019
HosgoodIII, H. Dean ; Chapman, Robert S. ; He, Xingzhou ; Hu, Wei ; Tian, Linwei ; Liu, Larry Z. ; Lai, Hong Chen ; Chen, Wei ; Rothman, Nathaniel ; Lan, Qing. / History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China. In: Lung Cancer. 2013 ; Vol. 81, No. 3. pp. 343-346.
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