Abstract
History of chronic lung diseases and household coal use for heating and cooking are established risk factors of lung cancer; however, few studies have been able to explore these risk factors simultaneously. Xuanwei, China, has some of the highest rates of lung cancer in China and most residents experience substantial in-home coal smoke exposures. Using a population-based case-control study of 498 lung cancer cases and 498 age-matched controls, we evaluated the risk of lung cancer in relation to coal smoke exposure and history of chronic lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, tuberculosis (TB), chronic bronchitis, and emphysema. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression adjusting for potential confounders. We observed an increased risk of lung cancer with history of any chronic lung disease among males (OR. = 14.2; 95%CI. = 4.3-46.9), females (OR. = 2.6; 95%CI. = 1.1-6.3), smokers (OR. = 12.7; 95%CI. = 3.5-45.8), and nonsmokers (OR. = 2.6; 95%CI. = 1.1-6.4). Specifically, TB (OR. = 83.7; 95%CI. = 11.0-634.7), COPD (OR. = 3.2; 95%CI. = 1.7-6.0), and emphysema and chronic bronchitis (OR. = 3.3; 95%CI. = 1.7-6.4) were associated with increased risks. These findings suggest that history of chronic lung diseases may also increase risk of lung cancer in populations with indoor coal smoke exposures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-346 |
| Number of pages | 4 |
| Journal | Lung Cancer |
| Volume | 81 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2013 |
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Keywords
- China
- Chronic lung disease
- Lung cancer
- Never smoking
- Xuanwei
ASJC Scopus subject areas
- Oncology
- Pulmonary and Respiratory Medicine
- Cancer Research
Cite this
History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China. / HosgoodIII, H. Dean; Chapman, Robert S.; He, Xingzhou; Hu, Wei; Tian, Linwei; Liu, Larry Z.; Lai, Hong Chen; Chen, Wei; Rothman, Nathaniel; Lan, Qing.
In: Lung Cancer, Vol. 81, No. 3, 09.2013, p. 343-346.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China
AU - HosgoodIII, H. Dean
AU - Chapman, Robert S.
AU - He, Xingzhou
AU - Hu, Wei
AU - Tian, Linwei
AU - Liu, Larry Z.
AU - Lai, Hong Chen
AU - Chen, Wei
AU - Rothman, Nathaniel
AU - Lan, Qing
PY - 2013/9
Y1 - 2013/9
N2 - History of chronic lung diseases and household coal use for heating and cooking are established risk factors of lung cancer; however, few studies have been able to explore these risk factors simultaneously. Xuanwei, China, has some of the highest rates of lung cancer in China and most residents experience substantial in-home coal smoke exposures. Using a population-based case-control study of 498 lung cancer cases and 498 age-matched controls, we evaluated the risk of lung cancer in relation to coal smoke exposure and history of chronic lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, tuberculosis (TB), chronic bronchitis, and emphysema. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression adjusting for potential confounders. We observed an increased risk of lung cancer with history of any chronic lung disease among males (OR. = 14.2; 95%CI. = 4.3-46.9), females (OR. = 2.6; 95%CI. = 1.1-6.3), smokers (OR. = 12.7; 95%CI. = 3.5-45.8), and nonsmokers (OR. = 2.6; 95%CI. = 1.1-6.4). Specifically, TB (OR. = 83.7; 95%CI. = 11.0-634.7), COPD (OR. = 3.2; 95%CI. = 1.7-6.0), and emphysema and chronic bronchitis (OR. = 3.3; 95%CI. = 1.7-6.4) were associated with increased risks. These findings suggest that history of chronic lung diseases may also increase risk of lung cancer in populations with indoor coal smoke exposures.
AB - History of chronic lung diseases and household coal use for heating and cooking are established risk factors of lung cancer; however, few studies have been able to explore these risk factors simultaneously. Xuanwei, China, has some of the highest rates of lung cancer in China and most residents experience substantial in-home coal smoke exposures. Using a population-based case-control study of 498 lung cancer cases and 498 age-matched controls, we evaluated the risk of lung cancer in relation to coal smoke exposure and history of chronic lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, tuberculosis (TB), chronic bronchitis, and emphysema. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression adjusting for potential confounders. We observed an increased risk of lung cancer with history of any chronic lung disease among males (OR. = 14.2; 95%CI. = 4.3-46.9), females (OR. = 2.6; 95%CI. = 1.1-6.3), smokers (OR. = 12.7; 95%CI. = 3.5-45.8), and nonsmokers (OR. = 2.6; 95%CI. = 1.1-6.4). Specifically, TB (OR. = 83.7; 95%CI. = 11.0-634.7), COPD (OR. = 3.2; 95%CI. = 1.7-6.0), and emphysema and chronic bronchitis (OR. = 3.3; 95%CI. = 1.7-6.4) were associated with increased risks. These findings suggest that history of chronic lung diseases may also increase risk of lung cancer in populations with indoor coal smoke exposures.
KW - China
KW - Chronic lung disease
KW - Lung cancer
KW - Never smoking
KW - Xuanwei
UR - http://www.scopus.com/inward/record.url?scp=84881664962&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881664962&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2013.06.019
DO - 10.1016/j.lungcan.2013.06.019
M3 - Article
C2 - 23891511
AN - SCOPUS:84881664962
VL - 81
SP - 343
EP - 346
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 3
ER -