History of histamine-releasing factor (HRF)/translationally controlled tumor protein (TCTP) including a potential therapeutic target in asthma and allergy

Susan M. MacDonald

Research output: Chapter in Book/Report/Conference proceedingChapter


Histamine-releasing factor (HRF) also known as translationally controlled tumor protein (TCTP) is a highly conserved, ubiquitous protein that has both intracellular and extracellular functions. Here we will highlight the subcloning of the molecule, its clinical implications, as well as an inducible-transgenic mouse. Particular attention will be paid to its extracellular functioning and its potential role as a therapeutic target in asthma and allergy. The cells and the cytokines that are produced when stimulated or primed by HRF/TCTP will be detailed as well as the downstream signaling pathway that HRF/TCTP elicits. While it was originally thought that HRF/TCTP interacted with IgE, the finding that cells not binding IgE also respond to HRF/TCTP called this interaction into question. HRF/TCTP or at least its mouse counterpart appears to interact with some, but not all IgE and IgG molecules. HRF/TCTP has been shown to activate multiple human cells including basophils, eosinophils, T cells, and B cells. Since many of the cells that are activated by HRF/TCTP participate in the allergic response, the extracellular functions of HRF/TCTP could exacerbate the allergic, inflammatory cascade. Particularly exciting is that small molecule agonists of the phosphatase SHIP-1 have been shown to modulate the P13 kinase/AKT pathway and may control inflammatory disorders. This review discusses this possibility in light of HRF/TCTP.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer Verlag
Number of pages18
StatePublished - 2017

Publication series

NameResults and Problems in Cell Differentiation
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412


  • Histamine-releasing factor (HRF)
  • Human basophils
  • Human eosinophils
  • Inducible-transgenic mouse
  • Interleukin 13
  • Interleukin 4
  • Mast cells
  • Src homology 2 domain-containing inositol 5’ phosphatase (SHIP-1)
  • Translationally controlled tumor protein (TCTP)

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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