Historical perspective of eukaryotic DNA replication

Research output: Chapter in Book/Report/Conference proceedingChapter


The replication of the genome of a eukaryotic cell is a complex process requiring the ordered assembly of multiprotein replisomes at many chromosomal sites. The process is strictly controlled during the cell cycle to ensure the complete and faithful transmission of genetic information to progeny cells. Our current understanding of the mechanisms of eukaryotic DNA replication has evolved over a period of more than 30 years through the efforts of many investigators. The aim of this perspective is to provide a brief history of the major advances during this period.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages41
StatePublished - Jan 1 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • DNA replication
  • Eukaryotes
  • Helicase
  • Initiator
  • Origin of DNA replication
  • Prereplicative complex
  • Replisome
  • Viral models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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