Historical Perspective and Current Challenges of Cancer Genomics

Graham Dellaire, Robert J. Arceci

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

From the first descriptions of cancer in Egypt around 3000 BC to our current "one week" whole-genome sequence, the history of integrating new ideas into the practice of medicine has been unrelenting, although not without its failures as well its successes. This chapter represents a brief historical summary of some of the key success stories in our understanding of cancer that has led to our current age of cancer genomics. As the Chinese proverb states, "When you drink from the well, remember who dug it", and reflecting on this rich and varied history, we conclude the chapter with a discussion of current and future challenges to the application of our new and developing understanding of cancer genomes to patient therapy.

Original languageEnglish (US)
Title of host publicationCancer Genomics: From Bench to Personalized Medicine
PublisherElsevier Inc.
Pages3-10
Number of pages8
ISBN (Print)9780123969675
DOIs
StatePublished - Dec 2013
Externally publishedYes

Fingerprint

Genomics
Genes
Medicine
Neoplasms
History
Aphorisms and Proverbs
Genome
Egypt
Therapeutics

Keywords

  • Chromoplexy
  • Chromothripsis
  • DNA microarrays
  • DNA sequencing
  • Epigenetics
  • Kataegis
  • Massively parallel sequencing
  • Philadelphia chromosome
  • RNA-sequencing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dellaire, G., & Arceci, R. J. (2013). Historical Perspective and Current Challenges of Cancer Genomics. In Cancer Genomics: From Bench to Personalized Medicine (pp. 3-10). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-396967-5.00001-3

Historical Perspective and Current Challenges of Cancer Genomics. / Dellaire, Graham; Arceci, Robert J.

Cancer Genomics: From Bench to Personalized Medicine. Elsevier Inc., 2013. p. 3-10.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dellaire, G & Arceci, RJ 2013, Historical Perspective and Current Challenges of Cancer Genomics. in Cancer Genomics: From Bench to Personalized Medicine. Elsevier Inc., pp. 3-10. https://doi.org/10.1016/B978-0-12-396967-5.00001-3
Dellaire G, Arceci RJ. Historical Perspective and Current Challenges of Cancer Genomics. In Cancer Genomics: From Bench to Personalized Medicine. Elsevier Inc. 2013. p. 3-10 https://doi.org/10.1016/B978-0-12-396967-5.00001-3
Dellaire, Graham ; Arceci, Robert J. / Historical Perspective and Current Challenges of Cancer Genomics. Cancer Genomics: From Bench to Personalized Medicine. Elsevier Inc., 2013. pp. 3-10
@inbook{1d736f26b0314f529b9758d97a2a97c7,
title = "Historical Perspective and Current Challenges of Cancer Genomics",
abstract = "From the first descriptions of cancer in Egypt around 3000 BC to our current {"}one week{"} whole-genome sequence, the history of integrating new ideas into the practice of medicine has been unrelenting, although not without its failures as well its successes. This chapter represents a brief historical summary of some of the key success stories in our understanding of cancer that has led to our current age of cancer genomics. As the Chinese proverb states, {"}When you drink from the well, remember who dug it{"}, and reflecting on this rich and varied history, we conclude the chapter with a discussion of current and future challenges to the application of our new and developing understanding of cancer genomes to patient therapy.",
keywords = "Chromoplexy, Chromothripsis, DNA microarrays, DNA sequencing, Epigenetics, Kataegis, Massively parallel sequencing, Philadelphia chromosome, RNA-sequencing",
author = "Graham Dellaire and Arceci, {Robert J.}",
year = "2013",
month = "12",
doi = "10.1016/B978-0-12-396967-5.00001-3",
language = "English (US)",
isbn = "9780123969675",
pages = "3--10",
booktitle = "Cancer Genomics: From Bench to Personalized Medicine",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Historical Perspective and Current Challenges of Cancer Genomics

AU - Dellaire, Graham

AU - Arceci, Robert J.

PY - 2013/12

Y1 - 2013/12

N2 - From the first descriptions of cancer in Egypt around 3000 BC to our current "one week" whole-genome sequence, the history of integrating new ideas into the practice of medicine has been unrelenting, although not without its failures as well its successes. This chapter represents a brief historical summary of some of the key success stories in our understanding of cancer that has led to our current age of cancer genomics. As the Chinese proverb states, "When you drink from the well, remember who dug it", and reflecting on this rich and varied history, we conclude the chapter with a discussion of current and future challenges to the application of our new and developing understanding of cancer genomes to patient therapy.

AB - From the first descriptions of cancer in Egypt around 3000 BC to our current "one week" whole-genome sequence, the history of integrating new ideas into the practice of medicine has been unrelenting, although not without its failures as well its successes. This chapter represents a brief historical summary of some of the key success stories in our understanding of cancer that has led to our current age of cancer genomics. As the Chinese proverb states, "When you drink from the well, remember who dug it", and reflecting on this rich and varied history, we conclude the chapter with a discussion of current and future challenges to the application of our new and developing understanding of cancer genomes to patient therapy.

KW - Chromoplexy

KW - Chromothripsis

KW - DNA microarrays

KW - DNA sequencing

KW - Epigenetics

KW - Kataegis

KW - Massively parallel sequencing

KW - Philadelphia chromosome

KW - RNA-sequencing

UR - http://www.scopus.com/inward/record.url?scp=84902405702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902405702&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-396967-5.00001-3

DO - 10.1016/B978-0-12-396967-5.00001-3

M3 - Chapter

AN - SCOPUS:84902405702

SN - 9780123969675

SP - 3

EP - 10

BT - Cancer Genomics: From Bench to Personalized Medicine

PB - Elsevier Inc.

ER -