Historical Perspective and Current Challenges of Cancer Genomics

Graham Dellaire; Robert J. Arceci

doi:10.1016/B978-0-12-396967-5.00001-3

Historical Perspective and Current Challenges of Cancer Genomics

Graham Dellaire, Robert J. Arceci

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

From the first descriptions of cancer in Egypt around 3000 BC to our current "one week" whole-genome sequence, the history of integrating new ideas into the practice of medicine has been unrelenting, although not without its failures as well its successes. This chapter represents a brief historical summary of some of the key success stories in our understanding of cancer that has led to our current age of cancer genomics. As the Chinese proverb states, "When you drink from the well, remember who dug it", and reflecting on this rich and varied history, we conclude the chapter with a discussion of current and future challenges to the application of our new and developing understanding of cancer genomes to patient therapy.

Original language	English (US)
Title of host publication	Cancer Genomics
Subtitle of host publication	From Bench to Personalized Medicine
Publisher	Elsevier Inc.
Pages	3-10
Number of pages	8
ISBN (Print)	9780123969675
DOIs	https://doi.org/10.1016/B978-0-12-396967-5.00001-3
State	Published - Dec 2013

Keywords

Chromoplexy
Chromothripsis
DNA microarrays
DNA sequencing
Epigenetics
Kataegis
Massively parallel sequencing
Philadelphia chromosome
RNA-sequencing

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/B978-0-12-396967-5.00001-3

Cite this

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KW - Chromothripsis

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KW - Epigenetics

KW - Kataegis

KW - Massively parallel sequencing

KW - Philadelphia chromosome

KW - RNA-sequencing

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ER -

Historical Perspective and Current Challenges of Cancer Genomics

Abstract

Keywords

ASJC Scopus subject areas

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