Historical Perspective and Current Challenges of Cancer Genomics

Graham Dellaire, Robert J. Arceci

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

From the first descriptions of cancer in Egypt around 3000 BC to our current "one week" whole-genome sequence, the history of integrating new ideas into the practice of medicine has been unrelenting, although not without its failures as well its successes. This chapter represents a brief historical summary of some of the key success stories in our understanding of cancer that has led to our current age of cancer genomics. As the Chinese proverb states, "When you drink from the well, remember who dug it", and reflecting on this rich and varied history, we conclude the chapter with a discussion of current and future challenges to the application of our new and developing understanding of cancer genomes to patient therapy.

Original languageEnglish (US)
Title of host publicationCancer Genomics
Subtitle of host publicationFrom Bench to Personalized Medicine
PublisherElsevier Inc.
Pages3-10
Number of pages8
ISBN (Print)9780123969675
DOIs
StatePublished - Dec 1 2013

Keywords

  • Chromoplexy
  • Chromothripsis
  • DNA microarrays
  • DNA sequencing
  • Epigenetics
  • Kataegis
  • Massively parallel sequencing
  • Philadelphia chromosome
  • RNA-sequencing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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