Histoplasmosis and subcutaneous nodules in a kidney transplant recipient: Erythema nodosum versus fungal panniculitis

S. F. Dufresne, R. E. Leblanc, S. X. Zhang, K. A. Marr, D. Neofytos

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Erythema nodosum (EN)-like lesions are a rare occurrence after solid organ transplantation. Differential diagnosis includes infective panniculitis, which can be a feature of progressive disseminated histoplasmosis (PDH), an uncommon but severe form affecting primarily immunocompromised hosts. We report on a fatal case of PDH, which presented as fungal panniculitis masquerading as EN in a renal allograft recipient 25 years after transplantation. We discuss the clinical, histopathological, and microbiological characteristics of this rare complication, with focus on its distinction from EN. This case emphasizes the central role of biopsy in transplant recipients presenting with cutaneous lesions, and the importance of clinicopathologic correlation and complementary microbiological investigations.

Original languageEnglish (US)
Pages (from-to)E58-E63
JournalTransplant Infectious Disease
Volume15
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • Erythema nodosum
  • Fungal panniculitis
  • Granulomatous panniculitis
  • Histoplasmosis
  • Infective panniculitis
  • Kidney transplant
  • Progressive disseminated histoplasmosis
  • Renal transplant
  • Solid organ transplantation

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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