Histoplasma granuloma of the conjunctiva

Purpose: To describe the clinical and pathologic features of a conjunctival granuloma resulting from Histoplasma capsulatum. Design: Clinicopathologic case report. Methods: Surgical excision of conjunctival lesion, histopathologic study with special stains, and a fluorescent antibody technique. Results: A conjunctiva granuloma was found to contain microorganisms, compatible with H. capsulatum, confirmed by a fluorescent antibody technique. The conjunctiva returned to normal. Conclusions: A focal granuloma of the conjunctiva contained H. capsulatum in a patient whose recent symptoms suggested primary infection. The conjunctival lesion was similar to mucocutaneous lesions seen in patients with systemic histoplasmosis.