Histopathological review of sebaceous carcinoma of the eyelid

Patricia Rusa Pereira, Alexandre Nakao Odashiro, Abelardo A. Rodrigues-Reyes, Zelia Correa, João Pessoa De Souza Filho, Miguel N. Burnier

Research output: Contribution to journalReview article

Abstract

Background: Sebaceous carcinoma of the eyelid can clinically mimic benign conditions, such as recurrent chalazion and inflammation and histopathologically squamous cell and basal cell carcinoma (BCC). This retrospective study was undertaken as an attempt to improve the characterization and consequently the diagnosis of these tumors. Methods: Retrospective analysis was performed on eyelid specimens diagnosed as sebaceous carcinoma retrieved from Henry C. Witelson Ophthalmic Pathology Registry, Canada and Hospital Luis S. Bulnes Pathology Registry, Mexico. Two independent, masked pathologists reviewed the H&E microslides. Results: Forty-four cases were retrieved, 31 from Canada and 13 from Mexico. Cytoplasmic vacuoles were observed in 48% of the cases. Eighty-four percent of the cases were classified as poorly differentiated lesions. Of these, 75% had features similar to squamous cell carcinoma (SqCC), some with dyskeratosis (30%) and 7% resembled BCC. Solid growth pattern was seen in 26.2% of the cases and lobular growth pattern in 26.2%. Superficial spread resembling Bowen-like disease was observed in 33% of the cases, pagetoid features in 33% and comedocarcinoma in 31.8%. Conclusion: Sebaceous carcinoma presented as a poorly differentiated lesion in most cases of this series, which suggests a possibility of misdiagnosis because of its similarities to SqCC.

Original languageEnglish (US)
Pages (from-to)496-501
Number of pages6
JournalJournal of Cutaneous Pathology
Volume32
Issue number7
DOIs
StatePublished - Aug 1 2005
Externally publishedYes

Fingerprint

Eyelids
Basal Cell Carcinoma
Mexico
Carcinoma
Canada
Registries
Squamous Cell Carcinoma
Chalazion
Pathology
Bowen's Disease
Growth
Vacuoles
Diagnostic Errors
Retrospective Studies
Epithelial Cells
Inflammation
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Pereira, P. R., Odashiro, A. N., Rodrigues-Reyes, A. A., Correa, Z., De Souza Filho, J. P., & Burnier, M. N. (2005). Histopathological review of sebaceous carcinoma of the eyelid. Journal of Cutaneous Pathology, 32(7), 496-501. https://doi.org/10.1111/j.0303-6987.2005.00371.x

Histopathological review of sebaceous carcinoma of the eyelid. / Pereira, Patricia Rusa; Odashiro, Alexandre Nakao; Rodrigues-Reyes, Abelardo A.; Correa, Zelia; De Souza Filho, João Pessoa; Burnier, Miguel N.

In: Journal of Cutaneous Pathology, Vol. 32, No. 7, 01.08.2005, p. 496-501.

Research output: Contribution to journalReview article

Pereira, PR, Odashiro, AN, Rodrigues-Reyes, AA, Correa, Z, De Souza Filho, JP & Burnier, MN 2005, 'Histopathological review of sebaceous carcinoma of the eyelid', Journal of Cutaneous Pathology, vol. 32, no. 7, pp. 496-501. https://doi.org/10.1111/j.0303-6987.2005.00371.x
Pereira PR, Odashiro AN, Rodrigues-Reyes AA, Correa Z, De Souza Filho JP, Burnier MN. Histopathological review of sebaceous carcinoma of the eyelid. Journal of Cutaneous Pathology. 2005 Aug 1;32(7):496-501. https://doi.org/10.1111/j.0303-6987.2005.00371.x
Pereira, Patricia Rusa ; Odashiro, Alexandre Nakao ; Rodrigues-Reyes, Abelardo A. ; Correa, Zelia ; De Souza Filho, João Pessoa ; Burnier, Miguel N. / Histopathological review of sebaceous carcinoma of the eyelid. In: Journal of Cutaneous Pathology. 2005 ; Vol. 32, No. 7. pp. 496-501.
@article{2c8abe301a5f4f26bd7ae50157ae2376,
title = "Histopathological review of sebaceous carcinoma of the eyelid",
abstract = "Background: Sebaceous carcinoma of the eyelid can clinically mimic benign conditions, such as recurrent chalazion and inflammation and histopathologically squamous cell and basal cell carcinoma (BCC). This retrospective study was undertaken as an attempt to improve the characterization and consequently the diagnosis of these tumors. Methods: Retrospective analysis was performed on eyelid specimens diagnosed as sebaceous carcinoma retrieved from Henry C. Witelson Ophthalmic Pathology Registry, Canada and Hospital Luis S. Bulnes Pathology Registry, Mexico. Two independent, masked pathologists reviewed the H&E microslides. Results: Forty-four cases were retrieved, 31 from Canada and 13 from Mexico. Cytoplasmic vacuoles were observed in 48{\%} of the cases. Eighty-four percent of the cases were classified as poorly differentiated lesions. Of these, 75{\%} had features similar to squamous cell carcinoma (SqCC), some with dyskeratosis (30{\%}) and 7{\%} resembled BCC. Solid growth pattern was seen in 26.2{\%} of the cases and lobular growth pattern in 26.2{\%}. Superficial spread resembling Bowen-like disease was observed in 33{\%} of the cases, pagetoid features in 33{\%} and comedocarcinoma in 31.8{\%}. Conclusion: Sebaceous carcinoma presented as a poorly differentiated lesion in most cases of this series, which suggests a possibility of misdiagnosis because of its similarities to SqCC.",
author = "Pereira, {Patricia Rusa} and Odashiro, {Alexandre Nakao} and Rodrigues-Reyes, {Abelardo A.} and Zelia Correa and {De Souza Filho}, {Jo{\~a}o Pessoa} and Burnier, {Miguel N.}",
year = "2005",
month = "8",
day = "1",
doi = "10.1111/j.0303-6987.2005.00371.x",
language = "English (US)",
volume = "32",
pages = "496--501",
journal = "Journal of Cutaneous Pathology",
issn = "0303-6987",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Histopathological review of sebaceous carcinoma of the eyelid

AU - Pereira, Patricia Rusa

AU - Odashiro, Alexandre Nakao

AU - Rodrigues-Reyes, Abelardo A.

AU - Correa, Zelia

AU - De Souza Filho, João Pessoa

AU - Burnier, Miguel N.

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Background: Sebaceous carcinoma of the eyelid can clinically mimic benign conditions, such as recurrent chalazion and inflammation and histopathologically squamous cell and basal cell carcinoma (BCC). This retrospective study was undertaken as an attempt to improve the characterization and consequently the diagnosis of these tumors. Methods: Retrospective analysis was performed on eyelid specimens diagnosed as sebaceous carcinoma retrieved from Henry C. Witelson Ophthalmic Pathology Registry, Canada and Hospital Luis S. Bulnes Pathology Registry, Mexico. Two independent, masked pathologists reviewed the H&E microslides. Results: Forty-four cases were retrieved, 31 from Canada and 13 from Mexico. Cytoplasmic vacuoles were observed in 48% of the cases. Eighty-four percent of the cases were classified as poorly differentiated lesions. Of these, 75% had features similar to squamous cell carcinoma (SqCC), some with dyskeratosis (30%) and 7% resembled BCC. Solid growth pattern was seen in 26.2% of the cases and lobular growth pattern in 26.2%. Superficial spread resembling Bowen-like disease was observed in 33% of the cases, pagetoid features in 33% and comedocarcinoma in 31.8%. Conclusion: Sebaceous carcinoma presented as a poorly differentiated lesion in most cases of this series, which suggests a possibility of misdiagnosis because of its similarities to SqCC.

AB - Background: Sebaceous carcinoma of the eyelid can clinically mimic benign conditions, such as recurrent chalazion and inflammation and histopathologically squamous cell and basal cell carcinoma (BCC). This retrospective study was undertaken as an attempt to improve the characterization and consequently the diagnosis of these tumors. Methods: Retrospective analysis was performed on eyelid specimens diagnosed as sebaceous carcinoma retrieved from Henry C. Witelson Ophthalmic Pathology Registry, Canada and Hospital Luis S. Bulnes Pathology Registry, Mexico. Two independent, masked pathologists reviewed the H&E microslides. Results: Forty-four cases were retrieved, 31 from Canada and 13 from Mexico. Cytoplasmic vacuoles were observed in 48% of the cases. Eighty-four percent of the cases were classified as poorly differentiated lesions. Of these, 75% had features similar to squamous cell carcinoma (SqCC), some with dyskeratosis (30%) and 7% resembled BCC. Solid growth pattern was seen in 26.2% of the cases and lobular growth pattern in 26.2%. Superficial spread resembling Bowen-like disease was observed in 33% of the cases, pagetoid features in 33% and comedocarcinoma in 31.8%. Conclusion: Sebaceous carcinoma presented as a poorly differentiated lesion in most cases of this series, which suggests a possibility of misdiagnosis because of its similarities to SqCC.

UR - http://www.scopus.com/inward/record.url?scp=22844447177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22844447177&partnerID=8YFLogxK

U2 - 10.1111/j.0303-6987.2005.00371.x

DO - 10.1111/j.0303-6987.2005.00371.x

M3 - Review article

C2 - 16008694

AN - SCOPUS:22844447177

VL - 32

SP - 496

EP - 501

JO - Journal of Cutaneous Pathology

JF - Journal of Cutaneous Pathology

SN - 0303-6987

IS - 7

ER -