Abstract
Histopathological activity was assessed in the skin tissue of 13 skin- smear negative, borderline tuberculoid leprosy patients after administration of a single dose of ROM (rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg) therapy. Biopsies taken just before therapy showed Mycobacterium leprae to be present in eight cases. After 6 months, only three showed granulomatous lesions and others showed only resolving or inactive lesions. Acid-fast bacilli (AFB) persisted in the nerves of three cases. At the end of 12 months, granulomas persisted in 2 out of 13 (15%) patients. No bacilli, however, were detected in any of them at the end of 12 months. This study demonstrated that 12 months after a single dose of ROM granuloma cleared in 85% of the patients and AFB were absent in all of them.
Original language | English (US) |
---|---|
Pages (from-to) | 409-413 |
Number of pages | 5 |
Journal | International Journal of Leprosy and Other Mycobacterial Diseases |
Volume | 67 |
Issue number | 4 |
State | Published - Dec 1999 |
Externally published | Yes |
ASJC Scopus subject areas
- Dermatology