Histopathological activity in paucibacillary leprosy patients after ROM therapy

Gigi J. Ebenezer, Charles K. Job

Research output: Contribution to journalArticle

Abstract

Histopathological activity was assessed in the skin tissue of 13 skin- smear negative, borderline tuberculoid leprosy patients after administration of a single dose of ROM (rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg) therapy. Biopsies taken just before therapy showed Mycobacterium leprae to be present in eight cases. After 6 months, only three showed granulomatous lesions and others showed only resolving or inactive lesions. Acid-fast bacilli (AFB) persisted in the nerves of three cases. At the end of 12 months, granulomas persisted in 2 out of 13 (15%) patients. No bacilli, however, were detected in any of them at the end of 12 months. This study demonstrated that 12 months after a single dose of ROM granuloma cleared in 85% of the patients and AFB were absent in all of them.

Original languageEnglish (US)
Pages (from-to)409-413
Number of pages5
JournalInternational Journal of Leprosy and Other Mycobacterial Diseases
Volume67
Issue number4
StatePublished - Dec 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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