Histopathologic Comparison of the Subsets of Lupus Erythematosus

Myles S. Jerdan, Antoinette F. Hood, G. William Moore, Jeffrey P. Callen

    Research output: Contribution to journalArticle

    Abstract

    A recent study by Bangert et al suggests that there are quantitative histologic differences that distinguish discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE). Utilizing criteria proposed by these authors, we examined 77 biopsy specimens from 63 patients with various forms of lupus erythematosus, but we were unable to predict the correct clinical subset. Using the clinical diagnosis of DLE as a positive reference standard, the sensitivity and specificity for the overall pathologic diagnosis of DLE were 55% and 42%, respectively. Statistically significant histologic factors favoring the diagnosis of DLE over SCLE in the present study were pilosebaceous atrophy, hyperkeratosis, parakeratosis, basement membrane thickening around the follicles, subepidermal edema, and vascular ectasia. These histologic variables were entered into a forward stepwise multivariate regression analysis to determine distinct predictors of DLE vs SCLE. This analysis showed that pilosebaceous atrophy was the only distinct significant predictor of DLE vs SCLE. These results suggest that the histologic differentiation of clinically defined DLE and SCLE cannot be established from the histologic features examined.

    Original languageEnglish (US)
    Pages (from-to)52-55
    Number of pages4
    JournalArchives of Dermatology
    Volume126
    Issue number1
    DOIs
    StatePublished - 1990

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    Discoid Lupus Erythematosus
    Cutaneous Lupus Erythematosus
    Atrophy
    Parakeratosis
    Pathologic Dilatations
    Basement Membrane
    Blood Vessels
    Edema
    Multivariate Analysis
    Regression Analysis
    Biopsy
    Sensitivity and Specificity

    ASJC Scopus subject areas

    • Dermatology

    Cite this

    Histopathologic Comparison of the Subsets of Lupus Erythematosus. / Jerdan, Myles S.; Hood, Antoinette F.; Moore, G. William; Callen, Jeffrey P.

    In: Archives of Dermatology, Vol. 126, No. 1, 1990, p. 52-55.

    Research output: Contribution to journalArticle

    Jerdan, Myles S. ; Hood, Antoinette F. ; Moore, G. William ; Callen, Jeffrey P. / Histopathologic Comparison of the Subsets of Lupus Erythematosus. In: Archives of Dermatology. 1990 ; Vol. 126, No. 1. pp. 52-55.
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    abstract = "A recent study by Bangert et al suggests that there are quantitative histologic differences that distinguish discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE). Utilizing criteria proposed by these authors, we examined 77 biopsy specimens from 63 patients with various forms of lupus erythematosus, but we were unable to predict the correct clinical subset. Using the clinical diagnosis of DLE as a positive reference standard, the sensitivity and specificity for the overall pathologic diagnosis of DLE were 55{\%} and 42{\%}, respectively. Statistically significant histologic factors favoring the diagnosis of DLE over SCLE in the present study were pilosebaceous atrophy, hyperkeratosis, parakeratosis, basement membrane thickening around the follicles, subepidermal edema, and vascular ectasia. These histologic variables were entered into a forward stepwise multivariate regression analysis to determine distinct predictors of DLE vs SCLE. This analysis showed that pilosebaceous atrophy was the only distinct significant predictor of DLE vs SCLE. These results suggest that the histologic differentiation of clinically defined DLE and SCLE cannot be established from the histologic features examined.",
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