TY - JOUR
T1 - Histopathologic characterization of hereditary benign prostatic hyperplasia
AU - Doehring, Christopher B.
AU - Sanda, Martin G.
AU - Partin, Alan
AU - Sauvageot, Jurga
AU - Juo, Hank
AU - Beaty, Terri H.
AU - Epstein, Jonathan
AU - Hill, Gary
AU - Walsh, Patrick C.
PY - 1996/10
Y1 - 1996/10
N2 - Objectives. Recent studies suggest the presence of a hereditary form of benign prostatic hyperplasia (H-BPH). This study was undertaken to characterize the histopathologic features of BPH in these men. Methods. Because study subjects with H-BPH were young (mean age 59 years) and had a large prostate (mean prostate weight 61 g), we compared the histopathologic findings in these men with those in two different control groups: (1) age- matched control subjects (mean age 59 years; mean prostate weight 31 g), and (2) prostate weight-matched control subjects (mean age 70 years; mean prostate weight 61 g). Using a color video image analysis system, we morphometrically determined stromal/epithelial ratios in histologic sections taken from 12 men with H-BPH, 36 age-matched control subjects, and 36 prostate weight-matched control subjects. Results. The stromal/epithelial ratio was 2.6 ± 1.4 in the men with H-BPH, 2.7 ± 1.7 in the age-matched control subjects, and 1.7 ± 0.9 in the prostate weight-matched control subjects. Regression analysis, which controlled for the differences in prostate weight or patient age between men with H-BPH and age-matched and prostate weight-matched control subjects, respectively, revealed a significant difference between men with H-BPH and prostate weight-matched control subjects (P = 0.015) but no difference from age-matched control subjects (P = 0.36). Conclusions. The larger prostates in young men with H- BPH are characterized by a higher stromal/epithelial ratio than are similar- sized prostates in older men with sporadic BPH. This finding gives rise to speculation that H-BPH is associated with an increase in stromal elements.
AB - Objectives. Recent studies suggest the presence of a hereditary form of benign prostatic hyperplasia (H-BPH). This study was undertaken to characterize the histopathologic features of BPH in these men. Methods. Because study subjects with H-BPH were young (mean age 59 years) and had a large prostate (mean prostate weight 61 g), we compared the histopathologic findings in these men with those in two different control groups: (1) age- matched control subjects (mean age 59 years; mean prostate weight 31 g), and (2) prostate weight-matched control subjects (mean age 70 years; mean prostate weight 61 g). Using a color video image analysis system, we morphometrically determined stromal/epithelial ratios in histologic sections taken from 12 men with H-BPH, 36 age-matched control subjects, and 36 prostate weight-matched control subjects. Results. The stromal/epithelial ratio was 2.6 ± 1.4 in the men with H-BPH, 2.7 ± 1.7 in the age-matched control subjects, and 1.7 ± 0.9 in the prostate weight-matched control subjects. Regression analysis, which controlled for the differences in prostate weight or patient age between men with H-BPH and age-matched and prostate weight-matched control subjects, respectively, revealed a significant difference between men with H-BPH and prostate weight-matched control subjects (P = 0.015) but no difference from age-matched control subjects (P = 0.36). Conclusions. The larger prostates in young men with H- BPH are characterized by a higher stromal/epithelial ratio than are similar- sized prostates in older men with sporadic BPH. This finding gives rise to speculation that H-BPH is associated with an increase in stromal elements.
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U2 - 10.1016/S0090-4295(96)00329-9
DO - 10.1016/S0090-4295(96)00329-9
M3 - Article
C2 - 8886078
AN - SCOPUS:0030273018
SN - 0090-4295
VL - 48
SP - 650
EP - 653
JO - Urology
JF - Urology
IS - 4
ER -