Abstract
Objective To determine the association of antibodies against angiotensin II type 1 receptor (AT1R Ab) and histopathologic changes seen in patients with kidney allograft rejection and negative donor specific HLA antibodies (DSA). Methods Stored sera from 27 patients who had biopsy-proven rejection in the absence of DSA were tested for AT1R Ab. Biopsy slides of all patients were re-examined and classified according to Banff 2013 criteria. Histopathologic changes were compared between AT1R positive and negative patients. Results 75% of patients with positive pre-transplant AT1R Ab had antibody mediated rejection (AMR) compared to 37% of AT1R Ab-negative patients. A trend towards increased interstitial inflammation was observed in the AT1R Ab positive group (p = 0.08). More patients in the AT1R Ab positive group had microcirculation inflammation (88% vs 58% with glomerulitis scores ≥1; 75% vs 58% with peritubular capillaritis scores ≥1). Conclusion In kidney transplant recipients with rejection and no DSA, a higher incidence of AMR and worse inflammation scores are observed in the presence of positive pre-transplant AT1R antibodies.
Original language | English (US) |
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Pages (from-to) | 350-356 |
Number of pages | 7 |
Journal | Human Immunology |
Volume | 78 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2017 |
Keywords
- Anti-angiotensin II
- Antibody
- Kidney transplant
- Non-HLA
- Rejection
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology