@article{afaeb42343804985bb6841fed879d348,
title = "Histopathologic and Immunologic Aspects of AlphaCor Artificial Corneal Failure",
abstract = "Purpose: To describe the histopathologic and immunologic characteristics of late artificial corneal failure in a small series of patients who underwent AlphaCor implantation and to elucidate the mechanisms involved. Design: Clinicopathologic case series. Methods: Three patients were diagnosed with corneal melting during the late postoperative period and required the removal of the devices. The explanted devices embedded within the corneal tissues were examined by light microscopy, electron microscopy, and immunohistochemical studies. Results: Light microscopic examination of the specimens disclosed adequate biointegration with no foreign body response. Immunofluorescence studies of the skirt exhibited expression of inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), and some interferon γ (IFN-γ). The keratocytes stained positively for Thy-1 and smooth muscle actin but negatively for CD34. Conclusions: Although these findings confirm the occurrence of biointegration, myofibroblastic differentiation of the ingrowing keratocytes is a prominent feature.",
author = "Marco Coassin and Cheng Zhang and Green, {W. Richard} and Aquavella, {James V.} and Akpek, {Esen K.}",
note = "Funding Information: This study was supported in part by a William and Mary Greve Scholarship from Research to Prevent Blindness, Inc, New York, New York; The Director{\textquoteright}s Discovery Fund of the Wilmer Eye Institute, Baltimore, Maryland (Dr Akpek.); and a departmental grant from Research to Prevent Blindness, Inc, New York, New York (Dr Aquavella.). The authors indicate no financial conflict of interest. Involved in design of study (E.K.A.); conduct of study (E.K.A., J.V.A., W.R.G., M.C., C.Z.); collection, management, analysis, and interpretation of data (W.R.G., E.K.A., J.V.A., M.C., C.Z.); and preparation, review, or approval of the manuscript (M.C., E.K.A., C.Z., J.V.A.). Surgeries were performed at two sites by Dr Akpek (The Wilmer Eye Institute) and Dr Aquavella (The University of Rochester Eye Institute). This study is in accordance with Health Insurance Portability and Accountability Act regulations and was reviewed and approved by the Institutional Review Boards of both Johns Hopkins University and the University of Rochester, in adherence to Declaration of Helsinki. ",
year = "2007",
month = nov,
doi = "10.1016/j.ajo.2007.07.025",
language = "English (US)",
volume = "144",
pages = "699--704.e4",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "5",
}