Histopathologic and immunohistochemical sequelae of bariatric embolization in a porcine model

Ben E. Paxton, Christopher L. Alley, Jennifer H. Crow, James Burchette, Clifford Weiss, Dara Kraitchman, Aravind Arepally, Charles Y. Kim

Research output: Contribution to journalArticle

Abstract

Purpose To evaluate the histopathologic sequelae of bariatric embolization on the gastric mucosa and to correlate with immunohistochemical evaluation of the gastric fundus, antrum, and duodenum. Materials and Methods This study was performed on 12 swine stomach and duodenum specimens after necropsy. Of the 12 swine, 6 had previously undergone bariatric embolization of the gastric fundus, and the 6 control swine had undergone a sham procedure with saline. Gross pathologic, histopathologic, and immunohistochemical examinations of the stomach and duodenum were performed. Specifically, mucosal integrity, fibrosis, ghrelin-expressing cells, and gastrin-expressing cells were assessed. Results Gross and histopathologic evaluation of treatment animals showed healing or healed mucosal ulcers in 50% of animals, with gastritis in 100% of treatment animals and in five of six control animals. The ghrelin-immunoreactive mean cell density was significantly lower in the gastric fundus in the treated animals compared with control animals (15.3 vs 22.0, P

Original languageEnglish (US)
Pages (from-to)455-461
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume25
Issue number3
DOIs
StatePublished - 2014

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Bariatrics
Swine
Gastric Fundus
Duodenum
Ghrelin
Stomach
Pyloric Antrum
Gastrin-Secreting Cells
Gastritis
Gastric Mucosa
Ulcer
Fibrosis
Cell Count
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Histopathologic and immunohistochemical sequelae of bariatric embolization in a porcine model. / Paxton, Ben E.; Alley, Christopher L.; Crow, Jennifer H.; Burchette, James; Weiss, Clifford; Kraitchman, Dara; Arepally, Aravind; Kim, Charles Y.

In: Journal of Vascular and Interventional Radiology, Vol. 25, No. 3, 2014, p. 455-461.

Research output: Contribution to journalArticle

Paxton, Ben E. ; Alley, Christopher L. ; Crow, Jennifer H. ; Burchette, James ; Weiss, Clifford ; Kraitchman, Dara ; Arepally, Aravind ; Kim, Charles Y. / Histopathologic and immunohistochemical sequelae of bariatric embolization in a porcine model. In: Journal of Vascular and Interventional Radiology. 2014 ; Vol. 25, No. 3. pp. 455-461.
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AU - Paxton, Ben E.

AU - Alley, Christopher L.

AU - Crow, Jennifer H.

AU - Burchette, James

AU - Weiss, Clifford

AU - Kraitchman, Dara

AU - Arepally, Aravind

AU - Kim, Charles Y.

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N2 - Purpose To evaluate the histopathologic sequelae of bariatric embolization on the gastric mucosa and to correlate with immunohistochemical evaluation of the gastric fundus, antrum, and duodenum. Materials and Methods This study was performed on 12 swine stomach and duodenum specimens after necropsy. Of the 12 swine, 6 had previously undergone bariatric embolization of the gastric fundus, and the 6 control swine had undergone a sham procedure with saline. Gross pathologic, histopathologic, and immunohistochemical examinations of the stomach and duodenum were performed. Specifically, mucosal integrity, fibrosis, ghrelin-expressing cells, and gastrin-expressing cells were assessed. Results Gross and histopathologic evaluation of treatment animals showed healing or healed mucosal ulcers in 50% of animals, with gastritis in 100% of treatment animals and in five of six control animals. The ghrelin-immunoreactive mean cell density was significantly lower in the gastric fundus in the treated animals compared with control animals (15.3 vs 22.0, P

AB - Purpose To evaluate the histopathologic sequelae of bariatric embolization on the gastric mucosa and to correlate with immunohistochemical evaluation of the gastric fundus, antrum, and duodenum. Materials and Methods This study was performed on 12 swine stomach and duodenum specimens after necropsy. Of the 12 swine, 6 had previously undergone bariatric embolization of the gastric fundus, and the 6 control swine had undergone a sham procedure with saline. Gross pathologic, histopathologic, and immunohistochemical examinations of the stomach and duodenum were performed. Specifically, mucosal integrity, fibrosis, ghrelin-expressing cells, and gastrin-expressing cells were assessed. Results Gross and histopathologic evaluation of treatment animals showed healing or healed mucosal ulcers in 50% of animals, with gastritis in 100% of treatment animals and in five of six control animals. The ghrelin-immunoreactive mean cell density was significantly lower in the gastric fundus in the treated animals compared with control animals (15.3 vs 22.0, P

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