Histone deacetylase 10-promoted autophagy as a druggable point of interference to improve the treatment response of advanced neuroblastomas

Ina Oehme, Marco Lodrini, Nathan R. Brady, Olaf Witt

Research output: Contribution to journalShort survey

Abstract

Neuroblastoma is the most common extracranial solid tumor in childhood. Despite intense multimodal therapy and many improvements through basic scientific and clinical research, the successful response of advanced-stage patients to chemotherapy remains poor. Autophagy is a cytoprotective mechanism that may help advanced cancer cells survive stressful conditions such as chemotherapy. Here we review our recent findings describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. These results propose a new and promising way to considerably improve treatment response in the neuroblastoma patient subgroup with the poorest outcome.

Original languageEnglish (US)
Pages (from-to)2163-2165
Number of pages3
JournalAutophagy
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Keywords

  • Drug resistance
  • HDAC-inhibitor
  • HDAC10
  • Lysosome
  • Macroautophagy
  • Neuroblastoma

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Histone deacetylase 10-promoted autophagy as a druggable point of interference to improve the treatment response of advanced neuroblastomas'. Together they form a unique fingerprint.

  • Cite this