TY - JOUR
T1 - Histological Characteristics of Breast Carcinoma in Blacks and Whites
AU - Chen, Vivien W.
AU - Correa, Pelayo
AU - Wu, Xiao Cheng
AU - Sobhan, Mahboob
AU - Kurman, Robert J.
AU - Eley, J. William
AU - Coates, Ralph
AU - Austin, Donald
AU - Reynolds, Peggy
AU - Muss, Hyman
AU - Hunter, Carrie P.
AU - Redmond, Carol
AU - Herman, Allen A.
AU - Edwards, Brenda K.
PY - 1994/3/1
Y1 - 1994/3/1
N2 - Tumor characteristics of 963 newly diagnosed invasive breast cancer cases from the population-based Black/ White Cancer Survival Study were evaluated. Representative slides of the tumors were requested from all participating hospitals of three metropolitan areas and reviewed by one expert pathologist, blinded in regard to the age and race of patients. Nine tumor characteristics were evaluated for black and white patients. After adjusting for age, stage, and metropolitan area, blacks were significantly more likely to have high grade nuclear atypia [odds ratio (OR) = 1.97, 95% confidence interval (CI) = 1.27-3.04]; high mitotic activity (OR = 2.05, 95% CI = 1.34-3.14), grade 3 tumors (OR = 1.58, 95% CI = 1.02-2.45), and more necrosis (OR = 1.51, 95% CI = 1.16-1.98); and less likely to have well defined tubulär formation (OR = 0.57, 95% CI = 0.42-0.77), marked fibrosis (OR = 0.65, 95% CI = 0.45-0.94), and positive estrogen receptor Status (OR = 0.78, 95% CI = 0.58-1.05). These black/white differences remained after controlling for socioeconomic Status (SES), body mass index, use of alcohol and tobacco, reproductive experience, and health care access and utilization. No significant racial differences were found for blood vessel invasion and lymphatic invasion. Although white women of high SES.
AB - Tumor characteristics of 963 newly diagnosed invasive breast cancer cases from the population-based Black/ White Cancer Survival Study were evaluated. Representative slides of the tumors were requested from all participating hospitals of three metropolitan areas and reviewed by one expert pathologist, blinded in regard to the age and race of patients. Nine tumor characteristics were evaluated for black and white patients. After adjusting for age, stage, and metropolitan area, blacks were significantly more likely to have high grade nuclear atypia [odds ratio (OR) = 1.97, 95% confidence interval (CI) = 1.27-3.04]; high mitotic activity (OR = 2.05, 95% CI = 1.34-3.14), grade 3 tumors (OR = 1.58, 95% CI = 1.02-2.45), and more necrosis (OR = 1.51, 95% CI = 1.16-1.98); and less likely to have well defined tubulär formation (OR = 0.57, 95% CI = 0.42-0.77), marked fibrosis (OR = 0.65, 95% CI = 0.45-0.94), and positive estrogen receptor Status (OR = 0.78, 95% CI = 0.58-1.05). These black/white differences remained after controlling for socioeconomic Status (SES), body mass index, use of alcohol and tobacco, reproductive experience, and health care access and utilization. No significant racial differences were found for blood vessel invasion and lymphatic invasion. Although white women of high SES.
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M3 - Article
C2 - 7519506
AN - SCOPUS:0028247226
SN - 1055-9965
VL - 3
SP - 127
EP - 135
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 2
ER -