Histologic study of the early events in oxalate induced intranephronic calculosis

S. R. Khan, B. Finlayson, R. L. Hackett

Research output: Contribution to journalArticlepeer-review

Abstract

The early phases of calcium oxalate crystal formation in rat kidneys after intraperitoneal challenge with sodium oxalate were examined. From the results the authors conclude that the crystals are formed intraluminally in the proximal tubules of the renal cortex. The size, number, and distribution of calcium oxalate particles depend on the amount of sodium oxalate injected and the time interval after its injection. Tubular necrosis and dilation were evident after administration of higher doses of sodium oxalate. The papillary tip and corticomedullary junction were the preferential sites for crystal localization after longer periods of injections of higher doses of sodium oxalate.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalInvestigative Urology
Volume17
Issue number3
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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