Histologic study of living response to artificially synthesized hydroxyapatite implant: 1-Year follow-up

Akira Saitoh, Yasuo Tsuda, Imran A. Bhutto, Takashi Kitaoka, Tsugio Amemiya

Research output: Contribution to journalArticlepeer-review

Abstract

We implanted artificially synthesized hydroxyapatite spheres in to the orbits of 13 rabbits after enucleation. The spheres were removed 1, 2, 3, 6, and 12 months after implantation and examined by light and scanning electron microscopy. Tissue breakdown and exposure of the artificially synthesized hydroxyapatite implants were not observed. Month after month, fibrovascular tissues gradually invaded the pores of the artificially synthesized hydroxyapatite spheres deeper and deeper. Although the hydroxyapatite we used was completely artificially synthesized, we observed a mild foreign-body reaction around the artificially synthesized hydroxyapatite spheres. After 12 months, however, relief of the foreign-body reaction had occurred. Hydroxyapatite spheres for orbital implants after enucleation without scleral enveloping are appropriate.

Original languageEnglish (US)
Pages (from-to)706-710
Number of pages5
JournalPlastic and reconstructive surgery
Volume98
Issue number4
DOIs
StatePublished - Sep 1996
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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