Histologic study of a shielded macula

J. B. Harlan, Daniel T. Weidenthal, W. Richard Green

Research output: Contribution to journalArticle

Abstract

Purpose: To illustrate the histologic changes at the macula of an eye shielded from focused light for 76 years. Age-related macular degeneration with a central, subretinal, fibrous scar was present in the fellow eye. Methods: Autopsy examination of both eyes of a 91-year-old man was performed. The superior half of the macular area of the shielded eye was studied by light microscopy, and the inferior half was studied by electron microscopy. Serial sections through the macular area of the fellow eye were prepared and studied. Results: The shielded eye contained basal laminar deposits up to 6.0 μm in thickness and basal linear deposits up to 1.0 μm in thickness in the macular area. The photoreceptor outer and inner segments of the outer nuclear layer were intact. The macular area of the fellow eye contained a two- component, vascularized, disciform scar that measured up to 250 μm in one area, with retinal pigment epithelial tears at the nasal and temporal margins. Extensive photoreceptor layer atrophy was present. Conclusions: Such marked asymmetry of macular degeneration in this case may be further evidence of the role of light exposure in the development of age related macular degeneration.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalRetina
Volume17
Issue number3
StatePublished - 1997

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Macular Degeneration
Light
Cicatrix
Retinal Pigments
Tears
Nose
Atrophy
Microscopy
Autopsy
Electron Microscopy

Keywords

  • Age-related macular degeneration
  • Asymmetric macular degeneration
  • Basal laminar deposit
  • Basal linear deposit
  • Bruch's membrane
  • Disciform scar
  • Light toxicity
  • Retinal pigment epithelial tear
  • Shielded macula

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Harlan, J. B., Weidenthal, D. T., & Green, W. R. (1997). Histologic study of a shielded macula. Retina, 17(3), 232-238.

Histologic study of a shielded macula. / Harlan, J. B.; Weidenthal, Daniel T.; Green, W. Richard.

In: Retina, Vol. 17, No. 3, 1997, p. 232-238.

Research output: Contribution to journalArticle

Harlan, JB, Weidenthal, DT & Green, WR 1997, 'Histologic study of a shielded macula', Retina, vol. 17, no. 3, pp. 232-238.
Harlan JB, Weidenthal DT, Green WR. Histologic study of a shielded macula. Retina. 1997;17(3):232-238.
Harlan, J. B. ; Weidenthal, Daniel T. ; Green, W. Richard. / Histologic study of a shielded macula. In: Retina. 1997 ; Vol. 17, No. 3. pp. 232-238.
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