Histologic phenotype on 1-year posttransplantation biopsy and allograft survival in HLA-incompatible kidney transplants

Adnan Sharif, Edward Kraus, Andrea A. Zachary, Bonnie E. Lonze, Susanna M. Nazarian, Dorry Segev, Nada Alachkar, Lois J Arend, Serena M Bagnasco, Lorraine C Racusen, Robert A. Montgomery

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The correlation between histopathologic phenotypes and allograft outcomes among patients desensitized for donor-specific antibody (HLA-incompatible) is unknown. METHODS: We analyzed 1-year biopsies from desensitized recipients transplanted between 1999 and 2010 and estimated graft survival for each histologic phenotype identified. Median time posttransplant for the 1-year biopsy was 367 days (interquartile range 357-388 days) and median follow-up of all patients post-1-year biopsy was 42 months (interquartile range 19.5-65 months). RESULTS: Transplant glomerulopathy was present in 25.0% of biopsies and resulted in worse graft survival (66.7% vs. 96.7%, P

Original languageEnglish (US)
Pages (from-to)541-547
Number of pages7
JournalTransplantation
Volume97
Issue number5
DOIs
StatePublished - Mar 15 2014

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Allografts
Transplants
Phenotype
Kidney
Biopsy
Graft Survival
Tissue Donors
Antibodies

Keywords

  • ABO incompatible
  • Desensitization
  • Histopathology
  • HLA incompatible
  • Incompatible transplantation
  • Kidney transplantation
  • Protocol biopsy

ASJC Scopus subject areas

  • Transplantation

Cite this

Histologic phenotype on 1-year posttransplantation biopsy and allograft survival in HLA-incompatible kidney transplants. / Sharif, Adnan; Kraus, Edward; Zachary, Andrea A.; Lonze, Bonnie E.; Nazarian, Susanna M.; Segev, Dorry; Alachkar, Nada; Arend, Lois J; Bagnasco, Serena M; Racusen, Lorraine C; Montgomery, Robert A.

In: Transplantation, Vol. 97, No. 5, 15.03.2014, p. 541-547.

Research output: Contribution to journalArticle

Sharif, Adnan ; Kraus, Edward ; Zachary, Andrea A. ; Lonze, Bonnie E. ; Nazarian, Susanna M. ; Segev, Dorry ; Alachkar, Nada ; Arend, Lois J ; Bagnasco, Serena M ; Racusen, Lorraine C ; Montgomery, Robert A. / Histologic phenotype on 1-year posttransplantation biopsy and allograft survival in HLA-incompatible kidney transplants. In: Transplantation. 2014 ; Vol. 97, No. 5. pp. 541-547.
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AU - Nazarian, Susanna M.

AU - Segev, Dorry

AU - Alachkar, Nada

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AU - Racusen, Lorraine C

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