Histologic pattern of early heart allograft rejection under cyclosporine treatment

K. Ueda, William A Baumgartner, W. E. Beschorner, M. A. Borkon, L. M. Soule, B. R. Reitz, A. Herskowitz

Research output: Contribution to journalArticle

Abstract

The histologic abnormalities associated with early heart rejection in cyclosporine-treated patients are not fully characterized. To study these abnormalities, Lewis rats received ACI heart-lung allografts and two weeks of cyclosporine treatment. Then the therapy was discontinued. Controls were sacrificed at that time; other animals were sacrificed three, six, and nine days later. The rejection score was determined solely by the percentage of necrotic myocardium, while 13 other histologic parameters were semi-quantitatively graded to identify parameters of early rejection of the heart. There was no evidence of myocardial necrosis or significant inflammation three days after discontinuation of therapy. At six and nine days, despite the absence of myocyte necrosis, there were significant increases in the grades for interstitial and endocardial inflammation, venous cuffing, perivascular inflammation with intermyocyte extension and arterial vasculitis. Our quantitative and semi-quantitative histologic analysis identified abnormalities of the early stage of heart rejection that may provide clues in defining rejection prior to the development of myocyte necrosis.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalJournal of Heart Transplantation
Volume4
Issue number3
StatePublished - 1984

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Cyclosporine
Allografts
Necrosis
Inflammation
Muscle Cells
Inbred ACI Rats
Therapeutics
Vasculitis
Myocardium
Lung

ASJC Scopus subject areas

  • Transplantation

Cite this

Ueda, K., Baumgartner, W. A., Beschorner, W. E., Borkon, M. A., Soule, L. M., Reitz, B. R., & Herskowitz, A. (1984). Histologic pattern of early heart allograft rejection under cyclosporine treatment. Journal of Heart Transplantation, 4(3), 296-301.

Histologic pattern of early heart allograft rejection under cyclosporine treatment. / Ueda, K.; Baumgartner, William A; Beschorner, W. E.; Borkon, M. A.; Soule, L. M.; Reitz, B. R.; Herskowitz, A.

In: Journal of Heart Transplantation, Vol. 4, No. 3, 1984, p. 296-301.

Research output: Contribution to journalArticle

Ueda, K, Baumgartner, WA, Beschorner, WE, Borkon, MA, Soule, LM, Reitz, BR & Herskowitz, A 1984, 'Histologic pattern of early heart allograft rejection under cyclosporine treatment', Journal of Heart Transplantation, vol. 4, no. 3, pp. 296-301.
Ueda, K. ; Baumgartner, William A ; Beschorner, W. E. ; Borkon, M. A. ; Soule, L. M. ; Reitz, B. R. ; Herskowitz, A. / Histologic pattern of early heart allograft rejection under cyclosporine treatment. In: Journal of Heart Transplantation. 1984 ; Vol. 4, No. 3. pp. 296-301.
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