TY - JOUR
T1 - Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas
AU - Fu, Yao S.
AU - Braun, Lundy
AU - Shah, Keerti V.
AU - Lawrence, W. Dwayne
AU - Robboy, Stanley J.
PY - 1983/11/1
Y1 - 1983/11/1
N2 - Fifty‐four cervical condylomatous lesions, with and without nuclear atypia, from 42 women, were studied with the Feulgen microspectrophotometric technique for nuclear DNA quantitation and an immunoperoxidase technique for human papillomavirus (HPV) antigen. All ordinary cervical condylomas (without atypia/dysplasia) had a diploid or polyploid nuclear DNA distribution; 61% had detectable HPV antigen. Among the cervical condylomas with atypia/dysplasia, 55% (17/31) had diploid or polyploid nuclear DNA pattern, and, of these, 59% (10/17) had demonstrable papillomavirus antigen. Fourteen (45%) were aneuploid lesions, 2 of which had a small number of cells with papillomavirus antigen (14%). These findings suggest that the majority of cervical condylomas are related to papillomavirus infection. That lesions with dysplasia, including high degrees of dysplasia, may also exhibit coexistence of papillomavirus infection suggests the possibility of an infectious etiology in the genesis of cervical squamous neoplasia.
AB - Fifty‐four cervical condylomatous lesions, with and without nuclear atypia, from 42 women, were studied with the Feulgen microspectrophotometric technique for nuclear DNA quantitation and an immunoperoxidase technique for human papillomavirus (HPV) antigen. All ordinary cervical condylomas (without atypia/dysplasia) had a diploid or polyploid nuclear DNA distribution; 61% had detectable HPV antigen. Among the cervical condylomas with atypia/dysplasia, 55% (17/31) had diploid or polyploid nuclear DNA pattern, and, of these, 59% (10/17) had demonstrable papillomavirus antigen. Fourteen (45%) were aneuploid lesions, 2 of which had a small number of cells with papillomavirus antigen (14%). These findings suggest that the majority of cervical condylomas are related to papillomavirus infection. That lesions with dysplasia, including high degrees of dysplasia, may also exhibit coexistence of papillomavirus infection suggests the possibility of an infectious etiology in the genesis of cervical squamous neoplasia.
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U2 - 10.1002/1097-0142(19831101)52:9<1705::AID-CNCR2820520926>3.0.CO;2-D
DO - 10.1002/1097-0142(19831101)52:9<1705::AID-CNCR2820520926>3.0.CO;2-D
M3 - Article
C2 - 6193864
AN - SCOPUS:0020514007
SN - 0008-543X
VL - 52
SP - 1705
EP - 1711
JO - Cancer
JF - Cancer
IS - 9
ER -