Histologic, Immunohistochemical, and Clinical Features of 27 Mammary Tumors in 18 Male Dogs

J. J. Bearss, F. Y. Schulman, D. Carter

Research output: Contribution to journalArticle

Abstract

Twenty-seven mammary tumors from 18 male (3 intact, 15 neutered) dogs were collected. The average age at diagnosis was 9.2 years (range, 2-14 years). Seven of the dogs were Cocker Spaniels. Five dogs had multiple mammary tumors. All tumors were benign. Twenty-six were simple adenomas with mixed acinar and papillary patterns. The acinar pattern was predominant in 17 cases. One adenoma was complex with a prominent myoepithelial component. The myoepithelial component of 25 of the 25 tumors was immunohistochemically positive for calponin and p63. In the cases for which relevant clinical information was available, there was no reported history of obesity, testicular tumors, or sex hormone therapy. Surgery was the only reported treatment for these tumors. Only 1 dog was reported to have developed an additional mammary tumor. None of the dogs for which case outcome was known died or was euthanatized as a result of mammary tumor. Although uncommon, mammary tumors do occur in male dogs. Although mammary tumors may be quite cellular, the presence of an intact myoepithelium, which can be demonstrated with immunohistochemistry for calponin and p63, indicates benignancy, as the clinical behavior documents.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalVeterinary Pathology
Volume49
Issue number4
DOIs
StatePublished - Jul 2012
Externally publishedYes

Fingerprint

mammary neoplasms (animal)
Dogs
Breast Neoplasms
dogs
neoplasms
adenoma
Adenoma
Testicular Hormones
Cocker Spaniel
Neoplasms
sex hormones
Testicular Neoplasms
Gonadal Steroid Hormones
immunohistochemistry
obesity
Obesity
surgery
Immunohistochemistry
therapeutics
Therapeutics

Keywords

  • dog
  • male
  • mammary
  • neoplasia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Histologic, Immunohistochemical, and Clinical Features of 27 Mammary Tumors in 18 Male Dogs. / Bearss, J. J.; Schulman, F. Y.; Carter, D.

In: Veterinary Pathology, Vol. 49, No. 4, 07.2012, p. 602-607.

Research output: Contribution to journalArticle

Bearss, J. J. ; Schulman, F. Y. ; Carter, D. / Histologic, Immunohistochemical, and Clinical Features of 27 Mammary Tumors in 18 Male Dogs. In: Veterinary Pathology. 2012 ; Vol. 49, No. 4. pp. 602-607.
@article{d92559a2e1424fe3be8a18d2e1c249b2,
title = "Histologic, Immunohistochemical, and Clinical Features of 27 Mammary Tumors in 18 Male Dogs",
abstract = "Twenty-seven mammary tumors from 18 male (3 intact, 15 neutered) dogs were collected. The average age at diagnosis was 9.2 years (range, 2-14 years). Seven of the dogs were Cocker Spaniels. Five dogs had multiple mammary tumors. All tumors were benign. Twenty-six were simple adenomas with mixed acinar and papillary patterns. The acinar pattern was predominant in 17 cases. One adenoma was complex with a prominent myoepithelial component. The myoepithelial component of 25 of the 25 tumors was immunohistochemically positive for calponin and p63. In the cases for which relevant clinical information was available, there was no reported history of obesity, testicular tumors, or sex hormone therapy. Surgery was the only reported treatment for these tumors. Only 1 dog was reported to have developed an additional mammary tumor. None of the dogs for which case outcome was known died or was euthanatized as a result of mammary tumor. Although uncommon, mammary tumors do occur in male dogs. Although mammary tumors may be quite cellular, the presence of an intact myoepithelium, which can be demonstrated with immunohistochemistry for calponin and p63, indicates benignancy, as the clinical behavior documents.",
keywords = "dog, male, mammary, neoplasia",
author = "Bearss, {J. J.} and Schulman, {F. Y.} and D. Carter",
year = "2012",
month = "7",
doi = "10.1177/0300985811402843",
language = "English (US)",
volume = "49",
pages = "602--607",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "4",

}

TY - JOUR

T1 - Histologic, Immunohistochemical, and Clinical Features of 27 Mammary Tumors in 18 Male Dogs

AU - Bearss, J. J.

AU - Schulman, F. Y.

AU - Carter, D.

PY - 2012/7

Y1 - 2012/7

N2 - Twenty-seven mammary tumors from 18 male (3 intact, 15 neutered) dogs were collected. The average age at diagnosis was 9.2 years (range, 2-14 years). Seven of the dogs were Cocker Spaniels. Five dogs had multiple mammary tumors. All tumors were benign. Twenty-six were simple adenomas with mixed acinar and papillary patterns. The acinar pattern was predominant in 17 cases. One adenoma was complex with a prominent myoepithelial component. The myoepithelial component of 25 of the 25 tumors was immunohistochemically positive for calponin and p63. In the cases for which relevant clinical information was available, there was no reported history of obesity, testicular tumors, or sex hormone therapy. Surgery was the only reported treatment for these tumors. Only 1 dog was reported to have developed an additional mammary tumor. None of the dogs for which case outcome was known died or was euthanatized as a result of mammary tumor. Although uncommon, mammary tumors do occur in male dogs. Although mammary tumors may be quite cellular, the presence of an intact myoepithelium, which can be demonstrated with immunohistochemistry for calponin and p63, indicates benignancy, as the clinical behavior documents.

AB - Twenty-seven mammary tumors from 18 male (3 intact, 15 neutered) dogs were collected. The average age at diagnosis was 9.2 years (range, 2-14 years). Seven of the dogs were Cocker Spaniels. Five dogs had multiple mammary tumors. All tumors were benign. Twenty-six were simple adenomas with mixed acinar and papillary patterns. The acinar pattern was predominant in 17 cases. One adenoma was complex with a prominent myoepithelial component. The myoepithelial component of 25 of the 25 tumors was immunohistochemically positive for calponin and p63. In the cases for which relevant clinical information was available, there was no reported history of obesity, testicular tumors, or sex hormone therapy. Surgery was the only reported treatment for these tumors. Only 1 dog was reported to have developed an additional mammary tumor. None of the dogs for which case outcome was known died or was euthanatized as a result of mammary tumor. Although uncommon, mammary tumors do occur in male dogs. Although mammary tumors may be quite cellular, the presence of an intact myoepithelium, which can be demonstrated with immunohistochemistry for calponin and p63, indicates benignancy, as the clinical behavior documents.

KW - dog

KW - male

KW - mammary

KW - neoplasia

UR - http://www.scopus.com/inward/record.url?scp=84862703438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862703438&partnerID=8YFLogxK

U2 - 10.1177/0300985811402843

DO - 10.1177/0300985811402843

M3 - Article

C2 - 21441113

AN - SCOPUS:84862703438

VL - 49

SP - 602

EP - 607

JO - Veterinary Pathology

JF - Veterinary Pathology

SN - 0300-9858

IS - 4

ER -