Histologic factors of prognostic significance in the glioblastoma multiforme

Peter C. Burger, Robin T. Vollmer

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


The pretreatment biopsy specimens from 184 cases of malignant gliomas from The National Brain Tumor Study Group were reviewed in order to determine which, if any, of nine histologic factors were useful in subdividing the glioblastoma multiforme. In the smaller group of cases treated with surgery and supportive care only, there was a strong negative correlation between cellularity and survival. For those cases treated with surgery and radiation only, and for the study as a whole, there was a positive relationship between survival and the presence of a giant cell neoplasm. We have concluded, on the basis of this limited sample of this select group of patients, that this latter feature offers a potential basis for subclassification of the glioblastoma multiforme.

Original languageEnglish (US)
Pages (from-to)1179-1186
Number of pages8
Issue number5
StatePublished - Sep 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Histologic factors of prognostic significance in the glioblastoma multiforme'. Together they form a unique fingerprint.

Cite this