TY - JOUR
T1 - Histologic factors of prognostic significance in the glioblastoma multiforme
AU - Burger, Peter C.
AU - Vollmer, Robin T.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1980/9/1
Y1 - 1980/9/1
N2 - The pretreatment biopsy specimens from 184 cases of malignant gliomas from The National Brain Tumor Study Group were reviewed in order to determine which, if any, of nine histologic factors were useful in subdividing the glioblastoma multiforme. In the smaller group of cases treated with surgery and supportive care only, there was a strong negative correlation between cellularity and survival. For those cases treated with surgery and radiation only, and for the study as a whole, there was a positive relationship between survival and the presence of a giant cell neoplasm. We have concluded, on the basis of this limited sample of this select group of patients, that this latter feature offers a potential basis for subclassification of the glioblastoma multiforme.
AB - The pretreatment biopsy specimens from 184 cases of malignant gliomas from The National Brain Tumor Study Group were reviewed in order to determine which, if any, of nine histologic factors were useful in subdividing the glioblastoma multiforme. In the smaller group of cases treated with surgery and supportive care only, there was a strong negative correlation between cellularity and survival. For those cases treated with surgery and radiation only, and for the study as a whole, there was a positive relationship between survival and the presence of a giant cell neoplasm. We have concluded, on the basis of this limited sample of this select group of patients, that this latter feature offers a potential basis for subclassification of the glioblastoma multiforme.
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U2 - 10.1002/1097-0142(19800901)46:5<1179::AID-CNCR2820460517>3.0.CO;2-0
DO - 10.1002/1097-0142(19800901)46:5<1179::AID-CNCR2820460517>3.0.CO;2-0
M3 - Article
C2 - 6260329
AN - SCOPUS:0018954567
VL - 46
SP - 1179
EP - 1186
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 5
ER -