Abstract
In 84 cases of keratoplasty, all patients had densely vascularized corneas and a history of prior exposure to HLA antigens by pregnancy, blood transfusion, or previous transplantation. Donors were selected on the basis of a negative crossmatch to avoid donor antigens to which the recipient was preimmunized. The overall rate of graft failure from rejection was 15%. A retrospective analysis of donor-recipient HLA matching in 103 high-risk cases showed no consistent correlation between the number of antigens shared and graft outcome. These findings indicated negative cross-match to be important in donor selection for keratoplasty in high-risk cases.
Original language | English (US) |
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Pages (from-to) | 595-604 |
Number of pages | 10 |
Journal | American journal of ophthalmology |
Volume | 86 |
Issue number | 5 |
DOIs | |
State | Published - Nov 1978 |
ASJC Scopus subject areas
- Ophthalmology