Histocompatibility (HLA) antigens and keratoplasty

Walter J. Stark; Hugh R. Taylor; Wilma B. Bias; A. Edward Maumenee

doi:10.1016/0002-9394(78)90174-5

Histocompatibility (HLA) antigens and keratoplasty

Walter J. Stark, Hugh R. Taylor, Wilma B. Bias, A. Edward Maumenee

School of Medicine

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

In 84 cases of keratoplasty, all patients had densely vascularized corneas and a history of prior exposure to HLA antigens by pregnancy, blood transfusion, or previous transplantation. Donors were selected on the basis of a negative crossmatch to avoid donor antigens to which the recipient was preimmunized. The overall rate of graft failure from rejection was 15%. A retrospective analysis of donor-recipient HLA matching in 103 high-risk cases showed no consistent correlation between the number of antigens shared and graft outcome. These findings indicated negative cross-match to be important in donor selection for keratoplasty in high-risk cases.

Original language	English (US)
Pages (from-to)	595-604
Number of pages	10
Journal	American journal of ophthalmology
Volume	86
Issue number	5
DOIs	https://doi.org/10.1016/0002-9394(78)90174-5
State	Published - Nov 1978

ASJC Scopus subject areas

Ophthalmology

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10.1016/0002-9394(78)90174-5

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@article{a883fdd1f6f643a58ee3e37cd0186fb4,

title = "Histocompatibility (HLA) antigens and keratoplasty",

abstract = "In 84 cases of keratoplasty, all patients had densely vascularized corneas and a history of prior exposure to HLA antigens by pregnancy, blood transfusion, or previous transplantation. Donors were selected on the basis of a negative crossmatch to avoid donor antigens to which the recipient was preimmunized. The overall rate of graft failure from rejection was 15%. A retrospective analysis of donor-recipient HLA matching in 103 high-risk cases showed no consistent correlation between the number of antigens shared and graft outcome. These findings indicated negative cross-match to be important in donor selection for keratoplasty in high-risk cases.",

author = "Stark, {Walter J.} and Taylor, {Hugh R.} and Bias, {Wilma B.} and Maumenee, {A. Edward}",

note = "Funding Information: From the Wilmer Ophthalmological Institute (Drs. Stark, Taylor, and Maumenee), and the Immunogenetics Laboratory (Dr. Bias) of the Johns Hopkins Hospital, Baltimore, Maryland. This work was supported in part by Grant EY01302 from the National Eye Institute (Dr. Stark). Reprint requests to Walter J. Stark, M.D., Wilmer Institute, Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205.",

year = "1978",

month = nov,

doi = "10.1016/0002-9394(78)90174-5",

language = "English (US)",

volume = "86",

pages = "595--604",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

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TY - JOUR

T1 - Histocompatibility (HLA) antigens and keratoplasty

AU - Stark, Walter J.

AU - Taylor, Hugh R.

AU - Bias, Wilma B.

AU - Maumenee, A. Edward

N1 - Funding Information: From the Wilmer Ophthalmological Institute (Drs. Stark, Taylor, and Maumenee), and the Immunogenetics Laboratory (Dr. Bias) of the Johns Hopkins Hospital, Baltimore, Maryland. This work was supported in part by Grant EY01302 from the National Eye Institute (Dr. Stark). Reprint requests to Walter J. Stark, M.D., Wilmer Institute, Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205.

PY - 1978/11

Y1 - 1978/11

N2 - In 84 cases of keratoplasty, all patients had densely vascularized corneas and a history of prior exposure to HLA antigens by pregnancy, blood transfusion, or previous transplantation. Donors were selected on the basis of a negative crossmatch to avoid donor antigens to which the recipient was preimmunized. The overall rate of graft failure from rejection was 15%. A retrospective analysis of donor-recipient HLA matching in 103 high-risk cases showed no consistent correlation between the number of antigens shared and graft outcome. These findings indicated negative cross-match to be important in donor selection for keratoplasty in high-risk cases.

AB - In 84 cases of keratoplasty, all patients had densely vascularized corneas and a history of prior exposure to HLA antigens by pregnancy, blood transfusion, or previous transplantation. Donors were selected on the basis of a negative crossmatch to avoid donor antigens to which the recipient was preimmunized. The overall rate of graft failure from rejection was 15%. A retrospective analysis of donor-recipient HLA matching in 103 high-risk cases showed no consistent correlation between the number of antigens shared and graft outcome. These findings indicated negative cross-match to be important in donor selection for keratoplasty in high-risk cases.

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JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 5

ER -

Histocompatibility (HLA) antigens and keratoplasty

Abstract

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