Abstract
In man there is an increased incidence of peptic ulcer after portacaval shunt. In the rat, 2 months after portacaval anastomosis, there is a generalized increase in the histamine content of the soft tissues, and the increase is most marked in the acid-secreting portion of the stomach. This appears to be secondary to increased activity of the histamine-synthesizing enzyme, histidine decarboxylase. A histidine decarboxylase inhibitor can prevent such hypersecretion of acid in the stomach of these animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1033-1034 |
| Number of pages | 2 |
| Journal | Science |
| Volume | 150 |
| Issue number | 3699 |
| State | Published - Dec 1 1965 |
ASJC Scopus subject areas
- General