Histamine synthesis and gastric secretion after portacaval shunt

Josef E. Fischer, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

In man there is an increased incidence of peptic ulcer after portacaval shunt. In the rat, 2 months after portacaval anastomosis, there is a generalized increase in the histamine content of the soft tissues, and the increase is most marked in the acid-secreting portion of the stomach. This appears to be secondary to increased activity of the histamine-synthesizing enzyme, histidine decarboxylase. A histidine decarboxylase inhibitor can prevent such hypersecretion of acid in the stomach of these animals.

Original languageEnglish (US)
Pages (from-to)1033-1034
Number of pages2
JournalScience
Volume150
Issue number3699
StatePublished - Dec 1 1965

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