Histamine synthesis and gastric secretion after portacaval shunt

Josef E. Fischer, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

In man there is an increased incidence of peptic ulcer after portacaval shunt. In the rat, 2 months after portacaval anastomosis, there is a generalized increase in the histamine content of the soft tissues, and the increase is most marked in the acid-secreting portion of the stomach. This appears to be secondary to increased activity of the histamine-synthesizing enzyme, histidine decarboxylase. A histidine decarboxylase inhibitor can prevent such hypersecretion of acid in the stomach of these animals.

Original languageEnglish (US)
Pages (from-to)1033-1034
Number of pages2
JournalScience
Volume150
Issue number3699
StatePublished - 1965

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Histidine Decarboxylase
Surgical Portacaval Shunt
Histamine
Stomach
Acids
Peptic Ulcer
Incidence
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Histamine synthesis and gastric secretion after portacaval shunt. / Fischer, Josef E.; Snyder, Solomon H.

In: Science, Vol. 150, No. 3699, 1965, p. 1033-1034.

Research output: Contribution to journalArticle

Fischer, JE & Snyder, SH 1965, 'Histamine synthesis and gastric secretion after portacaval shunt', Science, vol. 150, no. 3699, pp. 1033-1034.
Fischer, Josef E. ; Snyder, Solomon H. / Histamine synthesis and gastric secretion after portacaval shunt. In: Science. 1965 ; Vol. 150, No. 3699. pp. 1033-1034.
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