Histamine in nasal secretions

P. A. Eggleston; J. O. Hendley; J. M. Gwaltney; A. W. Eggleston; B. S. Leavell

doi:10.1159/000232103

Histamine in nasal secretions

P. A. Eggleston, J. O. Hendley, J. M. Gwaltney, A. W. Eggleston, B. S. Leavell

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The histamine content of secretions collected by small-volume nasal washes was assayed by a spectrophotofluorometric method. A wide range of histamine concentrations (< 5 - 1,519 ng/ml) was found. The mean concentration in secretions from normal individuals (91 ng/ml) was not significantly different from that found in allergic individuals (51 ng/ml). Females had significantly lower concentrations than did males. Sequential sampling in normals and allergics showed a great deal of daily variation in histamine content. This technically simple method may prove useful in examining the epidemiology and pathophysiology of allergic rhinitis.

Original language	English (US)
Pages (from-to)	193-200
Number of pages	8
Journal	Unknown Journal
Volume	57
Issue number	3
DOIs	https://doi.org/10.1159/000232103
State	Published - 1978

ASJC Scopus subject areas

Immunology and Allergy

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10.1159/000232103

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title = "Histamine in nasal secretions",

abstract = "The histamine content of secretions collected by small-volume nasal washes was assayed by a spectrophotofluorometric method. A wide range of histamine concentrations (< 5 - 1,519 ng/ml) was found. The mean concentration in secretions from normal individuals (91 ng/ml) was not significantly different from that found in allergic individuals (51 ng/ml). Females had significantly lower concentrations than did males. Sequential sampling in normals and allergics showed a great deal of daily variation in histamine content. This technically simple method may prove useful in examining the epidemiology and pathophysiology of allergic rhinitis.",

author = "Eggleston, {P. A.} and Hendley, {J. O.} and Gwaltney, {J. M.} and Eggleston, {A. W.} and Leavell, {B. S.}",

year = "1978",

doi = "10.1159/000232103",

language = "English (US)",

volume = "57",

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AU - Eggleston, P. A.

AU - Hendley, J. O.

AU - Gwaltney, J. M.

AU - Eggleston, A. W.

AU - Leavell, B. S.

PY - 1978

Y1 - 1978

N2 - The histamine content of secretions collected by small-volume nasal washes was assayed by a spectrophotofluorometric method. A wide range of histamine concentrations (< 5 - 1,519 ng/ml) was found. The mean concentration in secretions from normal individuals (91 ng/ml) was not significantly different from that found in allergic individuals (51 ng/ml). Females had significantly lower concentrations than did males. Sequential sampling in normals and allergics showed a great deal of daily variation in histamine content. This technically simple method may prove useful in examining the epidemiology and pathophysiology of allergic rhinitis.

AB - The histamine content of secretions collected by small-volume nasal washes was assayed by a spectrophotofluorometric method. A wide range of histamine concentrations (< 5 - 1,519 ng/ml) was found. The mean concentration in secretions from normal individuals (91 ng/ml) was not significantly different from that found in allergic individuals (51 ng/ml). Females had significantly lower concentrations than did males. Sequential sampling in normals and allergics showed a great deal of daily variation in histamine content. This technically simple method may prove useful in examining the epidemiology and pathophysiology of allergic rhinitis.

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Histamine in nasal secretions

Abstract

ASJC Scopus subject areas

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