Abstract
3H-Mepyramine labels specific histamine H1-receptors in brains of mice after intravenous injection. The potencies of H1-antihistamines in reducing 3H-mepyramine binding in vivo correspond to their pharmacological activities and show parallels with their affinities for 3H-mepyramine binding sites in isolated brain membranes. Several antidepressants are potent in competing for 3H-mepyramine binding in vivo as well as in vitro.
Original language | English (US) |
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Pages (from-to) | 177-181 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 64 |
Issue number | 2-3 |
DOIs | |
State | Published - Jun 13 1980 |
Keywords
- H-Mepyramine
- Histamine H-receptors
- Labeling in vivo
- Sedation
- Tricyclic antidepressants
ASJC Scopus subject areas
- Pharmacology