TY - JOUR
T1 - Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine
AU - Kitanaka, Junichi
AU - Kitanaka, Nobue
AU - Hall, F. Scott
AU - Uhl, George R.
AU - Tatsuta, Tomohiro
AU - Morita, Yoshio
AU - Tanaka, Koh Ichi
AU - Nishiyama, Nobuyoshi
AU - Takemura, Motohiko
PY - 2011/10
Y1 - 2011/10
N2 - The effects of the histamine H3 receptor agonists (R)-α- methylhistamine, imetit and immepip on methamphetamine (METH)-induced stereotypical behavior were examined in mice. The administration of METH (10 mg/kg, i.p.) to male ddY mice induced behaviors including persistent locomotion and stereotypical behaviors, which were classified into four categories: Stereotypical head-bobbing (1.9%), circling (1.7%), sniffing (14.3%), and biting (82.1%). Pretreatment with (R)-α-methylhistamine (3 and 10 mg/kg, i.p.) significantly decreasedstereotypical sniffing, but increased stereotypical biting induced by METH, in a dose-dependent manner. This effect of (R)-α-methylhistamine on behavior was mimicked by imetit or immepip (brain-penetrating selective histamine H3 receptor agonists; 10 mg/kg, i.p. for each drug). Hypothalamic histamine levels 1 h after METH challenge were significantly increased in mice pretreated with saline. These increases in histamine levels were significantly decreased by pretreatment with histamine H3 receptor agonists, effects which would appear to underlie the shift from METHinduced stereotypical sniffing to biting.
AB - The effects of the histamine H3 receptor agonists (R)-α- methylhistamine, imetit and immepip on methamphetamine (METH)-induced stereotypical behavior were examined in mice. The administration of METH (10 mg/kg, i.p.) to male ddY mice induced behaviors including persistent locomotion and stereotypical behaviors, which were classified into four categories: Stereotypical head-bobbing (1.9%), circling (1.7%), sniffing (14.3%), and biting (82.1%). Pretreatment with (R)-α-methylhistamine (3 and 10 mg/kg, i.p.) significantly decreasedstereotypical sniffing, but increased stereotypical biting induced by METH, in a dose-dependent manner. This effect of (R)-α-methylhistamine on behavior was mimicked by imetit or immepip (brain-penetrating selective histamine H3 receptor agonists; 10 mg/kg, i.p. for each drug). Hypothalamic histamine levels 1 h after METH challenge were significantly increased in mice pretreated with saline. These increases in histamine levels were significantly decreased by pretreatment with histamine H3 receptor agonists, effects which would appear to underlie the shift from METHinduced stereotypical sniffing to biting.
KW - Behavior
KW - Histamine
KW - Hypothalamus
KW - Methamphetamine
UR - http://www.scopus.com/inward/record.url?scp=80555135390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80555135390&partnerID=8YFLogxK
U2 - 10.1007/s11064-011-0500-8
DO - 10.1007/s11064-011-0500-8
M3 - Article
C2 - 21573995
AN - SCOPUS:80555135390
SN - 0364-3190
VL - 36
SP - 1824
EP - 1833
JO - Neurochemical Research
JF - Neurochemical Research
IS - 10
ER -