Histamie release in vitro: Inhibition by catecholamines and methylxanthines

L. M. Lichtenstein, S. Margolis

Research output: Contribution to journalArticlepeer-review

Abstract

Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3′,5′- adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.

Original languageEnglish (US)
Pages (from-to)902-903
Number of pages2
JournalScience
Volume161
Issue number3844
DOIs
StatePublished - 1968

ASJC Scopus subject areas

  • General

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