Hispanic Ethnicity and the Risk of Pediatric Leukemia Relapse

Ernest K. Amankwah, Greg A. Hale

Research output: Contribution to journalArticlepeer-review

Abstract

Limited knowledge currently exists on the disparity in pediatric leukemia relapse. This study compared the risk of pediatric leukemia relapse between Hispanic and non-Hispanic Whites. Study participants were children (<20 years) diagnosed with leukemia from January 2006 to December 2014 at the Johns Hopkins All Children’s Hospital, St. Petersburg, Florida. Hazard ratios and 95% confidence intervals for relapse-free survival were calculated using adjusted Cox regression. The study included 35 Hispanic and 94 non-Hispanic Whites. Among patients <10 years old, there was a significantly higher risk of relapse in Hispanic compared to non-Hispanic Whites (hazard ratio = 6.19, 95% confidence interval = 1.15-33.27). No association was observed for patients aged ≥10 years nor all participants combined. Although the finding of this study may suggest that ethnic disparity in pediatric leukemia relapse may exist in younger children, our finding is limited by the small sample size from a single institution. Therefore, future larger multiinstitutional studies are warranted.

Original languageEnglish (US)
Pages (from-to)656-659
Number of pages4
JournalClinical pediatrics
Volume57
Issue number6
DOIs
StatePublished - Jun 1 2018

Keywords

  • ethnicity
  • pediatric leukemia and relapse

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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