Hirsutism and evaluation of the dexamethasone suppression and chorionic gonadotropin stimulation test

Jesus M. Lopez, Claude J. Migeon, Georgeanna E S Jones

Research output: Contribution to journalArticle

Abstract

The present study was undertaken to assess the value of the dexamethasone (DXM) suppression and human chrionic gonadotropin (HCG) stimulation test in the differential diagnosis of hirsutism. A total number of 31 women were studied of whom 5 were a group of volunteers from a penal farm. Twenty-six were patients with hirsutism of varied etiology. In the presence of normal adrenal function, a lack of suppression of 17-ketosteroid excretion after 7 days of DXM administration suggests strongly the presence of an androgenic ovary (polycystic ovary syndrome or ovarian tumor). On the basis of the present findings, however, it would have to be concluded that a negative response to HCG stimulation does not exclude the possibility of a Stein-Leventhal syndrome and that the test is invalid if any evidence of adrenal hyperactivity exists. The study on a volunteer who had had previous ovariectomy showed no response to HCG stimulation.

Original languageEnglish (US)
Pages (from-to)749-758
Number of pages10
JournalAmerican Journal of Obstetrics and Gynecology
Volume98
Issue number6
StatePublished - Jul 15 1967

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Hirsutism
Chorionic Gonadotropin
Gonadotropins
Dexamethasone
Polycystic Ovary Syndrome
Volunteers
17-Ketosteroids
Ovariectomy
Ovary
Differential Diagnosis
Neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Hirsutism and evaluation of the dexamethasone suppression and chorionic gonadotropin stimulation test. / Lopez, Jesus M.; Migeon, Claude J.; Jones, Georgeanna E S.

In: American Journal of Obstetrics and Gynecology, Vol. 98, No. 6, 15.07.1967, p. 749-758.

Research output: Contribution to journalArticle

Lopez, Jesus M. ; Migeon, Claude J. ; Jones, Georgeanna E S. / Hirsutism and evaluation of the dexamethasone suppression and chorionic gonadotropin stimulation test. In: American Journal of Obstetrics and Gynecology. 1967 ; Vol. 98, No. 6. pp. 749-758.
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